PMID- 10441734 OWN - NLM STAT- MEDLINE DCOM- 19990923 LR - 20190905 IS - 0938-8990 (Print) IS - 0938-8990 (Linking) VI - 10 IP - 9 DP - 1999 Sep TI - Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus. PG - 853-7 AB - A subtractive cDNA library was used to identify differentially expressed genes in mouse strains that differ at If1, a locus that regulates response to interferon induction by Newcastle Disease Virus infection. Among the isolated clones, sequence analysis identified the ribosomal proteins L37a and S8 as well as cDNAs for thymosine beta4, the QM transcriptional factor, and a novel genetic sequence. Analysis of two multilocus mouse crosses showed that the thymosine beta4 gene, Ptmb4, is present as a single-copy gene that maps to distal Chr X. The L37a, S8, and QM clones are all members of large multilocus families. These five clones were used to determine the map locations for 37 loci, of which 31 had not previously been described. The novel genetic sequence, D3Ppr1, mapped to distal Chr 3 near the position of the If1 locus, suggesting it may be a candidate for this regulatory gene. FAU - Kozak, C A AU - Kozak CA AD - Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Building 4, Room 329, 4 Center Drive MSC 0460, Bethesda, Maryland 20982-0460, USA. FAU - Su, Y AU - Su Y FAU - Raj, N B AU - Raj NB FAU - Pitha, P M AU - Pitha PM LA - eng GR - AI19737/AI/NIAID NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Mamm Genome JT - Mammalian genome : official journal of the International Mammalian Genome Society JID - 9100916 RN - 0 (DNA Probes) RN - 0 (DNA, Complementary) RN - 0 (Interferon Type I) SB - IM MH - Animals MH - Base Sequence MH - Chromosome Mapping MH - DNA Probes/genetics MH - DNA, Complementary/genetics MH - Gene Expression MH - *Genes, Regulator MH - Interferon Type I/biosynthesis/*genetics MH - Mice MH - Mice, Inbred C57BL MH - Muridae MH - Recombination, Genetic MH - X Chromosome/genetics EDAT- 1999/08/12 00:00 MHDA- 1999/08/12 00:01 CRDT- 1999/08/12 00:00 PHST- 1999/08/12 00:00 [pubmed] PHST- 1999/08/12 00:01 [medline] PHST- 1999/08/12 00:00 [entrez] AID - MG99-668 [pii] AID - 10.1007/s003359901103 [doi] PST - ppublish SO - Mamm Genome. 1999 Sep;10(9):853-7. doi: 10.1007/s003359901103.