PMID- 10441588
OWN - NLM
STAT- MEDLINE
DCOM- 19991004
LR  - 20181113
IS  - 0002-9297 (Print)
IS  - 0002-9297 (Linking)
VI  - 65
IP  - 3
DP  - 1999 Sep
TI  - Interaction between the functional polymorphisms of the alcohol-metabolism genes 
      in protection against alcoholism.
PG  - 795-807
AB  - The genes that encode the major enzymes of alcohol metabolism, alcohol
      dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), exhibit functional
      polymorphism. The variant alleles ADH2*2 and ADH3*1, which encode high-activity
      ADH isoforms, and the ALDH2*2 allele, which encodes the low-activity form of
      ALDH2, protect against alcoholism in East Asians. To investigate possible
      interactions among these protective genes, we genotyped 340 alcoholic and 545
      control Han Chinese living in Taiwan at the ADH2, ADH3, and ALDH2 loci. After the
      influence of ALDH2*2 was controlled for, multiple logistic regression analysis
      indicated that allelic variation at ADH3 exerts no significant effect on the risk
      of alcoholism. This can be accounted for by linkage disequlibrium between ADH3*1 
      and ADH2*2 ALDH2*2 homozygosity, regardless of the ADH2 genotypes, was fully
      protective against alcoholism; no individual showing such homozygosity was found 
      among the alcoholics. Logistic regression analyses of the remaining six
      combinatorial genotypes of the polymorphic ADH2 and ALDH2 loci indicated that
      individuals carrying one or two copies of ADH2*2 and a single copy of ALDH2*2 had
      the lowest risk (ORs 0.04-0.05) for alcoholism, as compared with the ADH2*1/*1
      and ALDH2*1/*1 genotype. The disease risk associated with the
      ADH2*2/*2-ALDH2*1/*1 genotype appeared to be about half of that associated with
      the ADH2*1/*2-ALDH2*1/*1 genotype. The results suggest that protection afforded
      by the ADH2*2 allele may be independent of that afforded by ALDH2*2.
FAU - Chen, C C
AU  - Chen CC
AD  - Department of Adult Psychiatry, Taipei City Psychiatric Center, Taipei, Taiwan,
      Republic of China.
FAU - Lu, R B
AU  - Lu RB
FAU - Chen, Y C
AU  - Chen YC
FAU - Wang, M F
AU  - Wang MF
FAU - Chang, Y C
AU  - Chang YC
FAU - Li, T K
AU  - Li TK
FAU - Yin, S J
AU  - Yin SJ
LA  - eng
GR  - AA02342/AA/NIAAA NIH HHS/United States
GR  - AA07611/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (Isoenzymes)
RN  - 3K9958V90M (Ethanol)
RN  - EC 1.1.1.1 (Alcohol Dehydrogenase)
RN  - EC 1.2.1.3 (Aldehyde Dehydrogenase)
SB  - IM
MH  - Adult
MH  - Alcohol Dehydrogenase/*genetics/metabolism
MH  - Alcoholism/enzymology/*genetics/metabolism
MH  - Aldehyde Dehydrogenase/*genetics/metabolism
MH  - China/ethnology
MH  - Ethanol/*metabolism
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genetic Variation/genetics
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Isoenzymes/genetics/metabolism
MH  - Linkage Disequilibrium
MH  - Logistic Models
MH  - Male
MH  - Multifactorial Inheritance/genetics
MH  - Odds Ratio
MH  - Polymorphism, Genetic/*genetics
MH  - Taiwan
PMC - PMC1377988
EDAT- 1999/08/12 10:00
MHDA- 2000/03/21 09:00
CRDT- 1999/08/12 10:00
PHST- 1999/08/12 10:00 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/08/12 10:00 [entrez]
AID - S0002-9297(07)62333-7 [pii]
AID - 10.1086/302540 [doi]
PST - ppublish
SO  - Am J Hum Genet. 1999 Sep;65(3):795-807. doi: 10.1086/302540.