PMID- 10440867
OWN - NLM
STAT- MEDLINE
DCOM- 19991018
LR  - 20091119
IS  - 0265-9247 (Print)
IS  - 0265-9247 (Linking)
VI  - 21
IP  - 8
DP  - 1999 Aug
TI  - A node between proliferation, apoptosis, and growth arrest.
PG  - 704-9
AB  - Paradoxically, oncogenes and growth factors can induce proliferation and promote 
      cellular survival but can also cause apoptosis and growth arrest. What determines
      whether a cell decides to proliferate, arrest growth, or die? Mitogens and
      activators of mitogen-activated pathways initiate the simultaneous production of 
      proliferative (cyclins) and anti-proliferative (CDK inhibitors such as
      p21WAF1/CIP1) signals. Quiescent cells may respond to these signals by
      proliferation whereas proliferating cells may respond by growth arrest. Although 
      pro-apoptotic oncoproteins, which constitute the downstream pathway (cyclin D,
      E2F, c-myc) directly induce proliferation, the activation of the upstream steps
      (growth factor receptors, Ras, cytoplasmic kinases) is required to prevent
      apoptosis.
CI  - Copyright 1999 John Wiley & Sons, Inc.
FAU - Blagosklonny, M V
AU  - Blagosklonny MV
AD  - Medicine Branch, National Cancer Institute, Bldg. 10, R 12N226, NIH, Bethesda,
      Maryland 20892, USA. mikhailb@box-m.nih.gov
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Bioessays
JT  - BioEssays : news and reviews in molecular, cellular and developmental biology
JID - 8510851
RN  - 0 (Cyclins)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
SB  - IM
MH  - Animals
MH  - Apoptosis/genetics/*physiology
MH  - Cell Division/genetics/*physiology
MH  - Cyclin-Dependent Kinases/physiology
MH  - Cyclins/physiology
MH  - Humans
MH  - Models, Biological
MH  - Oncogenes
MH  - Signal Transduction
RF  - 72
EDAT- 1999/08/10 00:00
MHDA- 1999/08/10 00:01
CRDT- 1999/08/10 00:00
PHST- 1999/08/10 00:00 [pubmed]
PHST- 1999/08/10 00:01 [medline]
PHST- 1999/08/10 00:00 [entrez]
AID - 10.1002/(SICI)1521-1878(199908)21:8<704::AID-BIES10>3.0.CO;2-5 [pii]
AID - 10.1002/(SICI)1521-1878(199908)21:8<704::AID-BIES10>3.0.CO;2-5 [doi]
PST - ppublish
SO  - Bioessays. 1999 Aug;21(8):704-9. doi:
      10.1002/(SICI)1521-1878(199908)21:8<704::AID-BIES10>3.0.CO;2-5.