PMID- 10439047
OWN - NLM
STAT- MEDLINE
DCOM- 19990813
LR  - 20190607
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 30
DP  - 1999 Jul 29
TI  - The transcription coactivator HTIF1 and a related protein are fused to the RET
      receptor tyrosine kinase in childhood papillary thyroid carcinomas.
PG  - 4388-93
AB  - Children exposed to radioactive iodine as a consequence of the Chernobyl reactor 
      accident have an increased risk of papillary thyroid carcinomas (PTC). The
      predominant molecular lesions in these tumors are rearrangements of the RET
      receptor tyrosine kinase (tk). Here we report on two novel types of RET
      rearrangement, PTC6 and 7, and describe the fusion products and the ret fused
      gene (rfg) proteins. Like the other rfg proteins identified so far they are
      ubiquitously expressed, not membrane-bound and contain coiled coil domains
      required for constitutive activation of the ret tk domain. In the PTC6
      rearrangement the ret tk domain is fused to the aminoterminal part of the human
      transcription intermediary factor htif 1. In the PTC7 rearrangement the ret tk
      domain is fused to a novel protein that is strongly related to htif1. Like htif1 
      it contains a RBCC motif (ring finger, B boxes, coiled coil domain) located in
      the aminoterminal part and a phd finger and a bromodomain in the carboxyterminal 
      part. Htif1 and related proteins are transcription coactivators for nuclear
      receptors, thus participating in controlling cellular development,
      differentiation and homeostasis. This is the first report on their involvement in
      human thyroid carcinogenesis.
FAU - Klugbauer, S
AU  - Klugbauer S
AD  - Institute of Pathology, Ludwig Maximilians University of Munich, Germany.
FAU - Rabes, H M
AU  - Rabes HM
LA  - eng
SI  - GENBANK/AJ132948
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Drosophila Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (transcriptional intermediary factor 1)
RN  - 63231-63-0 (RNA)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-ret)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Ret protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Blotting, Northern
MH  - Carcinoma, Papillary/genetics/*metabolism
MH  - Child, Preschool
MH  - *Drosophila Proteins
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - Neoplasms, Radiation-Induced/*genetics
MH  - Nuclear Proteins/*chemistry/genetics
MH  - Power Plants
MH  - Proto-Oncogene Proteins/*chemistry/genetics
MH  - Proto-Oncogene Proteins c-ret
MH  - RNA/analysis
MH  - Radioactive Hazard Release
MH  - Receptor Protein-Tyrosine Kinases/*chemistry/genetics
MH  - Republic of Belarus
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Homology, Amino Acid
MH  - Thyroid Neoplasms/genetics/*metabolism
MH  - Transcription Factors/*chemistry/genetics
MH  - Ukraine
EDAT- 1999/08/10 00:00
MHDA- 1999/08/10 00:01
CRDT- 1999/08/10 00:00
PHST- 1999/08/10 00:00 [pubmed]
PHST- 1999/08/10 00:01 [medline]
PHST- 1999/08/10 00:00 [entrez]
AID - 10.1038/sj.onc.1202824 [doi]
PST - ppublish
SO  - Oncogene. 1999 Jul 29;18(30):4388-93. doi: 10.1038/sj.onc.1202824.