PMID- 10438934
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20131121
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 163
IP  - 4
DP  - 1999 Aug 15
TI  - APCs express DCIR, a novel C-type lectin surface receptor containing an
      immunoreceptor tyrosine-based inhibitory motif.
PG  - 1973-83
AB  - We have identified a novel member of the calcium-dependent (C-type) lectin
      family. This molecule, designated DCIR (for dendritic cell (DC) immunoreceptor), 
      is a type II membrane glycoprotein of 237 aa with a single carbohydrate
      recognition domain (CRD), closest in homology to those of the macrophage lectin
      and hepatic asialoglycoprotein receptors. The intracellular domain of DCIR
      contains a consensus immunoreceptor tyrosine-based inhibitory motif. A mouse
      cDNA, encoding a homologous protein has been identified. Northern blot analysis
      showed DCIR mRNA to be predominantly transcribed in hematopoietic tissues. The
      gene encoding human DCIR was localized to chromosome 12p13, in a region close to 
      the NK gene complex. Unlike members of this complex, DCIR displays a typical
      lectin CRD rather than an NK cell type extracellular domain, and was expressed on
      DC, monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on 
      NK and T cells. DCIR was strongly expressed by DC derived from blood monocytes
      cultured with GM-CSF and IL-4. DCIR was mostly expressed by monocyte-related
      rather than Langerhans cell related DC obtained from CD34+ progenitor cells.
      Finally, DCIR expression was down-regulated by signals inducing DC maturation
      such as CD40 ligand, LPS, or TNF-alpha. Thus, DCIR is differentially expressed on
      DC depending on their origin and stage of maturation/activation. DCIR represents 
      a novel surface molecule expressed by Ag presenting cells, and of potential
      importance in regulation of DC function.
FAU - Bates, E E
AU  - Bates EE
AD  - Laboratory for Immunological Research, Schering-Plough, Dardilly, France.
      elizabeth.bates@spcorp.com
FAU - Fournier, N
AU  - Fournier N
FAU - Garcia, E
AU  - Garcia E
FAU - Valladeau, J
AU  - Valladeau J
FAU - Durand, I
AU  - Durand I
FAU - Pin, J J
AU  - Pin JJ
FAU - Zurawski, S M
AU  - Zurawski SM
FAU - Patel, S
AU  - Patel S
FAU - Abrams, J S
AU  - Abrams JS
FAU - Lebecque, S
AU  - Lebecque S
FAU - Garrone, P
AU  - Garrone P
FAU - Saeland, S
AU  - Saeland S
LA  - eng
SI  - GENBANK/AJ133532
SI  - GENBANK/AJ133533
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (CLEC4A protein, human)
RN  - 0 (DNA, Complementary)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Mitogen)
RN  - 42HK56048U (Tyrosine)
SB  - AIM
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - B-Lymphocytes/metabolism
MH  - Base Sequence
MH  - Cell Differentiation/genetics/immunology
MH  - Cells, Cultured
MH  - Chromosomes, Human, Pair 12
MH  - Cloning, Molecular
MH  - DNA, Complementary/isolation & purification
MH  - Dendritic Cells/cytology/immunology/*metabolism
MH  - Gene Dosage
MH  - Hematopoietic Stem Cells/metabolism
MH  - Humans
MH  - Intracellular Fluid/metabolism
MH  - *Lectins, C-Type
MH  - Liver/metabolism
MH  - Lymphoid Tissue/metabolism
MH  - Macrophages/immunology/metabolism
MH  - Membrane Glycoproteins/*biosynthesis/chemistry/genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family/immunology
MH  - Organ Specificity/genetics
MH  - Peptide Fragments/*biosynthesis/chemistry/genetics
MH  - *Receptors, Immunologic
MH  - Receptors, Mitogen/*biosynthesis/chemistry/genetics
MH  - Sequence Homology, Amino Acid
MH  - Tyrosine/metabolism
EDAT- 1999/08/10 00:00
MHDA- 1999/08/10 00:01
CRDT- 1999/08/10 00:00
PHST- 1999/08/10 00:00 [pubmed]
PHST- 1999/08/10 00:01 [medline]
PHST- 1999/08/10 00:00 [entrez]
AID - ji_v163n4p1973 [pii]
PST - ppublish
SO  - J Immunol. 1999 Aug 15;163(4):1973-83.