PMID- 10437792
OWN - NLM
STAT- MEDLINE
DCOM- 19990816
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 455
IP  - 3
DP  - 1999 Jul 23
TI  - Identification of three novel members of the calcium-dependent chloride channel
      (CaCC) family predominantly expressed in the digestive tract and trachea.
PG  - 295-301
AB  - Three novel human sequences showing striking homology to the recently described
      bovine Ca2+/calmodulin kinase II-dependent epithelial chloride channel bCaCC have
      been identified in an expressed sequence tags database. Full-length clones were
      isolated using a 5' RACE approach. The encoded predicted proteins display 65%
      overall homology to bCaCC. Tissue expression patterns of the corresponding genes,
      designated as hCaCC-1, -2 and -3, appear to be highly restricted, with the first 
      two genes primarily expressed in the digestive tract. Another original feature as
      compared to the CaCC family members is the fact that hCaCC-2 also shows
      expression in the brain. Taken together these findings demonstrate the existence 
      of several CaCC-like genes in humans, some of which display distinct tissue
      specificity patterns within the CaCC subfamily of chloride channels.
FAU - Agnel, M
AU  - Agnel M
AD  - Synthelabo Recherche, Genomic Biology Department, Rueil-Malmaison, France.
      Magnel@rueil.synthelabo.fr
FAU - Vermat, T
AU  - Vermat T
FAU - Culouscou, J M
AU  - Culouscou JM
LA  - eng
SI  - GENBANK/AF127035
SI  - GENBANK/AF127036
SI  - GENBANK/AF127980
SI  - SWISSPROT/P54281
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Chloride Channels)
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Calcium/*metabolism
MH  - Cattle
MH  - Chloride Channels/*genetics/metabolism
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Digestive System/*metabolism
MH  - Expressed Sequence Tags
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - RNA, Messenger/genetics/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
MH  - Tissue Distribution
MH  - Trachea/*metabolism
EDAT- 1999/08/07 00:00
MHDA- 1999/08/07 00:01
CRDT- 1999/08/07 00:00
PHST- 1999/08/07 00:00 [pubmed]
PHST- 1999/08/07 00:01 [medline]
PHST- 1999/08/07 00:00 [entrez]
AID - S0014-5793(99)00891-1 [pii]
AID - 10.1016/s0014-5793(99)00891-1 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Jul 23;455(3):295-301. doi: 10.1016/s0014-5793(99)00891-1.