PMID- 10436048
OWN - NLM
STAT- MEDLINE
DCOM- 19990901
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 16
DP  - 1999 Aug 15
TI  - Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite
      outgrowth and tau expression in PC12 cells.
PG  - 6907-17
AB  - The embryonic lethal abnormal vision (ELAV)-like proteins are mRNA-binding
      proteins that regulate mRNA stability. The neuronal members of this family are
      required for neuronal differentiation. We identified the binding region of
      purified HuD protein to a target neuronal mRNA encoding for the tau
      microtubule-associated protein and demonstrated an in vivo interaction between
      the ELAV-like protein and its target tau mRNA. We show that treatment of neuronal
      cells with antisense oligodeoxynucleotides directed against HuD blocks the
      induction of neurite outgrowth and decreases the levels of tau mRNAs, indicating 
      that the ELAV-like proteins are required for neuronal differentiation.
FAU - Aranda-Abreu, G E
AU  - Aranda-Abreu GE
AD  - Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot,
      Israel.
FAU - Behar, L
AU  - Behar L
FAU - Chung, S
AU  - Chung S
FAU - Furneaux, H
AU  - Furneaux H
FAU - Ginzburg, I
AU  - Ginzburg I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for
      Neuroscience
JID - 8102140
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (ELAV Proteins)
RN  - 0 (ELAV-Like Protein 4)
RN  - 0 (ELAVL4 protein, human)
RN  - 0 (EXC-7 protein, C elegans)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - *Caenorhabditis elegans Proteins
MH  - Cell Differentiation/physiology
MH  - Cell Polarity
MH  - ELAV Proteins
MH  - ELAV-Like Protein 4
MH  - Humans
MH  - Microtubules/chemistry
MH  - Molecular Sequence Data
MH  - Molecular Weight
MH  - *Nerve Tissue Proteins
MH  - Neurites/*physiology
MH  - Neurons/*cytology
MH  - Oligonucleotides, Antisense/pharmacology
MH  - PC12 Cells
MH  - RNA, Messenger/metabolism
MH  - RNA-Binding Proteins/genetics/*physiology
MH  - Rats
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - tau Proteins/*genetics
PMC - PMC6782881
EDAT- 1999/08/06 00:00
MHDA- 1999/08/06 00:01
CRDT- 1999/08/06 00:00
PHST- 1999/08/06 00:00 [pubmed]
PHST- 1999/08/06 00:01 [medline]
PHST- 1999/08/06 00:00 [entrez]
PST - ppublish
SO  - J Neurosci. 1999 Aug 15;19(16):6907-17.