PMID- 10436023
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20181113
IS  - 1059-1524 (Print)
IS  - 1059-1524 (Linking)
VI  - 10
IP  - 8
DP  - 1999 Aug
TI  - Molecular interaction map of the mammalian cell cycle control and DNA repair
      systems.
PG  - 2703-34
AB  - Eventually to understand the integrated function of the cell cycle regulatory
      network, we must organize the known interactions in the form of a diagram, map,
      and/or database. A diagram convention was designed capable of unambiguous
      representation of networks containing multiprotein complexes, protein
      modifications, and enzymes that are substrates of other enzymes. To facilitate
      linkage to a database, each molecular species is symbolically represented only
      once in each diagram. Molecular species can be located on the map by means of
      indexed grid coordinates. Each interaction is referenced to an annotation list
      where pertinent information and references can be found. Parts of the network are
      grouped into functional subsystems. The map shows how multiprotein complexes
      could assemble and function at gene promoter sites and at sites of DNA damage. It
      also portrays the richness of connections between the p53-Mdm2 subsystem and
      other parts of the network.
FAU - Kohn, K W
AU  - Kohn KW
AD  - Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer
      Institute, Bethesda, Maryland 20892, USA. kohnk@dc37a.nci.nih.gov
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Mol Biol Cell
JT  - Molecular biology of the cell
JID - 9201390
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Cyclins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (E2F Transcription Factors)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Retinoblastoma Protein)
RN  - 0 (Retinoblastoma-Binding Protein 1)
RN  - 0 (Transcription Factor DP1)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.3.2.27 (MDM2 protein, human)
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
SB  - IM
MH  - Animals
MH  - *Carrier Proteins
MH  - Cell Cycle/*physiology
MH  - *Cell Cycle Proteins
MH  - Cyclins/genetics/metabolism
MH  - *DNA Repair
MH  - *DNA-Binding Proteins
MH  - E2F Transcription Factors
MH  - Humans
MH  - Mammals
MH  - *Nuclear Proteins
MH  - Proto-Oncogene Proteins/genetics/metabolism
MH  - Proto-Oncogene Proteins c-mdm2
MH  - Retinoblastoma Protein/genetics/metabolism
MH  - Retinoblastoma-Binding Protein 1
MH  - Transcription Factor DP1
MH  - Transcription Factors/genetics/metabolism
MH  - Tumor Suppressor Protein p53/genetics/metabolism
RF  - 263
PMC - PMC25504
EDAT- 1999/08/06 00:00
MHDA- 1999/08/06 00:01
CRDT- 1999/08/06 00:00
PHST- 1999/08/06 00:00 [pubmed]
PHST- 1999/08/06 00:01 [medline]
PHST- 1999/08/06 00:00 [entrez]
AID - 10.1091/mbc.10.8.2703 [doi]
PST - ppublish
SO  - Mol Biol Cell. 1999 Aug;10(8):2703-34. doi: 10.1091/mbc.10.8.2703.