PMID- 10435629
OWN - NLM
STAT- MEDLINE
DCOM- 19990817
LR  - 20081121
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 27
DP  - 1999 Jul 8
TI  - Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of
      loss of heterozygosity.
PG  - 4044-6
AB  - To determine the frequency of Wnt/Wingless beta catenin pathway alteration in
      human hepatocellular carcinoma, a beta catenin and APC gene mutation screening
      was performed in a series of 119 tumors. An activating beta catenin mutation in
      exon 3 was found in 18% of the cases. Among tumors lacking beta catenin mutation,
      no APC mutation has been evidenced in a subset of 30 cases tested. The
      correlation between beta catenin mutation status and chromosome segment deletions
      was studied on a set of 48 hyperploid tumors. Chromosome 1p, 4q and 16p deletions
      were significantly associated with the absence of beta catenin mutation (P<0.05).
      Furthermore the Fractional Allelic Loss was significantly smaller in the beta
      catenin mutated tumors than in the non-mutated tumors (0.12 versus 022). Taken
      together, these results suggest, the existence of two carcinogenesis mechanisms. 
      The first mechanism implies a beta catenin activating mutation associated with a 
      low rate of loss of heterozygosity. The second mechanism, operating in a context 
      of chromosomal instability, would involve tumor suppressor genes.
FAU - Legoix, P
AU  - Legoix P
AD  - Centre d'Etude du Polymorphisme Humain, INSERM U434 Laboratoire de Genetique des 
      Tumeurs, Fondation Jean Dausset/CEPH, Paris, France.
FAU - Bluteau, O
AU  - Bluteau O
FAU - Bayer, J
AU  - Bayer J
FAU - Perret, C
AU  - Perret C
FAU - Balabaud, C
AU  - Balabaud C
FAU - Belghiti, J
AU  - Belghiti J
FAU - Franco, D
AU  - Franco D
FAU - Thomas, G
AU  - Thomas G
FAU - Laurent-Puig, P
AU  - Laurent-Puig P
FAU - Zucman-Rossi, J
AU  - Zucman-Rossi J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (Cadherins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Wnt Proteins)
RN  - 0 (Wnt1 Protein)
RN  - 0 (Zebrafish Proteins)
RN  - 0 (beta Catenin)
RN  - 0 (wg protein, Drosophila)
SB  - IM
MH  - Aneuploidy
MH  - Cadherins/genetics
MH  - Carcinoma, Hepatocellular/*genetics
MH  - Cytoskeletal Proteins/*genetics
MH  - DNA Mutational Analysis
MH  - *Drosophila Proteins
MH  - Genes, APC
MH  - Humans
MH  - Liver Neoplasms/*genetics
MH  - *Loss of Heterozygosity
MH  - *Mutation
MH  - Proto-Oncogene Proteins/genetics
MH  - *Trans-Activators
MH  - Wnt Proteins
MH  - Wnt1 Protein
MH  - *Zebrafish Proteins
MH  - beta Catenin
EDAT- 1999/08/06 00:00
MHDA- 1999/08/06 00:01
CRDT- 1999/08/06 00:00
PHST- 1999/08/06 00:00 [pubmed]
PHST- 1999/08/06 00:01 [medline]
PHST- 1999/08/06 00:00 [entrez]
AID - 10.1038/sj.onc.1202800 [doi]
PST - ppublish
SO  - Oncogene. 1999 Jul 8;18(27):4044-6. doi: 10.1038/sj.onc.1202800.