PMID- 10435627
OWN - NLM
STAT- MEDLINE
DCOM- 19990817
LR  - 20071114
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 27
DP  - 1999 Jul 8
TI  - Cloning of TACC1, an embryonically expressed, potentially transforming coiled
      coil containing gene, from the 8p11 breast cancer amplicon.
PG  - 4032-8
AB  - Amplification of several chromosomal regions have been observed in human breast
      carcinomas. One such region, 8p11, is amplified in 10-15% of tumor samples.
      Although the FGFR1 gene is located close to this region, and is often included
      within the amplicon, the observation that tumors exhibiting 8p11 amplification do
      not always overexpress FGFR1 suggests that another gene located close to FGFR1 is
      involved in the tumorigenic process. We now report the precise location of four
      expressed sequence tags (ESTs) within this region and the cloning of a novel
      gene, designated TACC1 (transforming acidic coiled coil gene 1), which encodes an
      8 kb transcript and which is expressed at high levels during early embryogenesis.
      Constitutive expression of this gene under the control of the cytomegalovirus
      (CMV) promoter in mouse fibroblasts, results in cellular transformation and
      anchorage independent growth, suggesting that inappropriate expression can impart
      a proliferative advantage. This observation raises the possibility that
      amplification of TACC1 could promote malignant growth, thereby making TACC1 an
      attractive candidate for the gene promoting tumorigenicity as a result of the
      8p11 amplification in human breast cancers.
FAU - Still, I H
AU  - Still IH
AD  - Center for Molecular Genetics, The Lerner Research Institute, Cleveland Clinic
      Foundation, Ohio 44195, USA.
FAU - Hamilton, M
AU  - Hamilton M
FAU - Vince, P
AU  - Vince P
FAU - Wolfman, A
AU  - Wolfman A
FAU - Cowell, J K
AU  - Cowell JK
LA  - eng
SI  - GENBANK/AF049910
GR  - GM49652/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Fetal Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (TACC1 protein, human)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Breast Neoplasms/*genetics
MH  - Cell Transformation, Neoplastic/chemistry/*genetics/pathology
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Cloning, Molecular
MH  - Fetal Proteins/biosynthesis/chemistry/genetics
MH  - *Gene Amplification
MH  - Genes, Neoplasm
MH  - Humans
MH  - Mice
MH  - *Microtubule-Associated Proteins
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Neoplasm Proteins/biosynthesis/chemistry/genetics
MH  - *Nuclear Proteins
MH  - Organ Specificity/genetics
MH  - Protein Structure, Secondary
EDAT- 1999/08/06 00:00
MHDA- 1999/08/06 00:01
CRDT- 1999/08/06 00:00
PHST- 1999/08/06 00:00 [pubmed]
PHST- 1999/08/06 00:01 [medline]
PHST- 1999/08/06 00:00 [entrez]
AID - 10.1038/sj.onc.1202801 [doi]
PST - ppublish
SO  - Oncogene. 1999 Jul 8;18(27):4032-8. doi: 10.1038/sj.onc.1202801.