PMID- 10435576
OWN - NLM
STAT- MEDLINE
DCOM- 19990811
LR  - 20190915
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 11
IP  - 1
DP  - 1999 Jul
TI  - Coordinate regulation of B cell differentiation by the transcription factors EBF 
      and E2A.
PG  - 21-31
AB  - The transcription factors EBF and E2A are required at a similar step in early B
      cell differentiation. EBF and E2A synergistically upregulate transcription of
      endogenous B cell-specific genes in a non-B cell line. Here, we examine a genetic
      collaboration between these factors in regulating B lymphopoiesis. We find that
      Ebf+/- E2a+/- mice display a marked defect in pro-B cell differentiation at a
      stage later than observed in the single homozygous mutant mice. Pro-B cells from 
      Ebf+/- E2a+/- mice show reduced expression of lymphoid-specific transcripts,
      including Pax5, Rag1, Rag2, and mb-1. We also show that EBF directly binds and
      activates the Pax5 promoter. Together, these data show collaboration between EBF 
      and E2A and provide insight into the hierarchy of transcription factors that
      regulate B lymphocyte differentiation.
FAU - O'Riordan, M
AU  - O'Riordan M
AD  - Howard Hughes Medical Institute, Department of Microbiology and Immunology,
      University of California, San Francisco 94143, USA.
FAU - Grosschedl, R
AU  - Grosschedl R
LA  - eng
SI  - GENBANK/AF148961
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Ebf1 protein, mouse)
RN  - 0 (Epitopes, B-Lymphocyte)
RN  - 0 (Immunoglobulin lambda-Chains)
RN  - 0 (Nuclear Proteins)
RN  - 0 (PAX5 Transcription Factor)
RN  - 0 (Pax5 protein, mouse)
RN  - 0 (TCF Transcription Factors)
RN  - 0 (Tcf7l1 protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factor 7-Like 1 Protein)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - B-Lymphocyte Subsets/metabolism/pathology
MH  - B-Lymphocytes/*cytology/*metabolism/pathology
MH  - Bone Marrow Cells/pathology
MH  - Cell Differentiation/genetics/immunology
MH  - DNA-Binding Proteins/biosynthesis/genetics/metabolism/*physiology
MH  - Enhancer Elements, Genetic/immunology
MH  - Epitopes, B-Lymphocyte/genetics/metabolism
MH  - Gene Expression Regulation/immunology
MH  - Genetic Carrier Screening
MH  - Helix-Loop-Helix Motifs/genetics/*immunology
MH  - Immunoglobulin lambda-Chains/genetics
MH  - Lymphopenia/genetics/immunology/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/genetics/metabolism
MH  - PAX5 Transcription Factor
MH  - Promoter Regions, Genetic/immunology
MH  - Stem Cells/metabolism/pathology
MH  - TCF Transcription Factors
MH  - Trans-Activators/biosynthesis/genetics/metabolism/*physiology
MH  - Transcription Factor 7-Like 1 Protein
MH  - Transcription Factors/biosynthesis/genetics/*immunology/metabolism
EDAT- 1999/08/06 00:00
MHDA- 1999/08/06 00:01
CRDT- 1999/08/06 00:00
PHST- 1999/08/06 00:00 [pubmed]
PHST- 1999/08/06 00:01 [medline]
PHST- 1999/08/06 00:00 [entrez]
AID - S1074-7613(00)80078-3 [pii]
AID - 10.1016/s1074-7613(00)80078-3 [doi]
PST - ppublish
SO  - Immunity. 1999 Jul;11(1):21-31. doi: 10.1016/s1074-7613(00)80078-3.