PMID- 10433968
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 236
IP  - 1
DP  - 1999 Aug 5
TI  - Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23.
PG  - 79-86
AB  - A cellular disintegrin, also called MDC and ADAM is a recently discovered gene
      family that encodes protein with disintegrin-like and metalloprotease-like
      domains. We have reported the identification of human cDNAs encoding novel ADAM
      family proteins that we named MDC2 and MDC3 because of their structural
      similarity to the MDC (Sagane, K. et al., 1998. Biochem. J. 334, 93-98). The
      Human Gene Nomenclature Committee assigned the gene symbols ADAM11 for the MDC,
      ADAM22 for the MDC2 and ADAM23 for the MDC3. Here we report the isolation of
      three novel murine cDNAs encoding the proteins closely related to the human
      ADAM11, ADAM22 and ADAM23. Their chromosomal locations in the mouse were
      identified by interspecies backcross mapping. The loci of these murine ADAM genes
      were in good accordance with the location of each human ortholog, ADAM11, ADAM22 
      and ADAM23. These findings suggest that three murine cDNAs that we have isolated 
      are the murine ADAM11, ADAM22 and ADAM23 cDNAs. Northern blot analysis shows that
      all of these three murine ADAMs were highly expressed in the mouse brain. The
      structures of these ADAM proteins strongly suggest that they could function as
      integrin receptors. The implications of the cellular disintegrins in neural
      development are discussed.
FAU - Sagane, K
AU  - Sagane K
AD  - Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3, Tokodai, Tsukuba, Ibaraki 
      300-2635, Japan. kl-sagane@eisai.co.jp
FAU - Yamazaki, K
AU  - Yamazaki K
FAU - Mizui, Y
AU  - Mizui Y
FAU - Tanaka, I
AU  - Tanaka I
LA  - eng
SI  - GENBANK/AB009673
SI  - GENBANK/AB009674
SI  - GENBANK/AB009676
PT  - Journal Article
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (DNA, Complementary)
RN  - 0 (Disintegrins)
RN  - 0 (Integrins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - EC 3.4.24.- (ADAM 11 protein, mouse)
RN  - EC 3.4.24.- (ADAM Proteins)
RN  - EC 3.4.24.- (Adam22 protein, mouse)
RN  - EC 3.4.24.- (Adam23 protein, mouse)
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - ADAM Proteins
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/metabolism
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - DNA, Complementary/analysis
MH  - *Disintegrins
MH  - Integrins/genetics
MH  - Membrane Proteins/*genetics
MH  - Metalloendopeptidases/*genetics
MH  - Mice
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Nerve Tissue Proteins/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
EDAT- 1999/08/06 00:00
MHDA- 1999/08/06 00:01
CRDT- 1999/08/06 00:00
PHST- 1999/08/06 00:00 [pubmed]
PHST- 1999/08/06 00:01 [medline]
PHST- 1999/08/06 00:00 [entrez]
AID - S0378-1119(99)00253-X [pii]
AID - 10.1016/s0378-1119(99)00253-x [doi]
PST - ppublish
SO  - Gene. 1999 Aug 5;236(1):79-86. doi: 10.1016/s0378-1119(99)00253-x.