PMID- 10433824
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20190523
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 212
IP  - 2
DP  - 1999 Aug 15
TI  - Vertebrate homologs of Drosophila suppressor of fused interact with the gli
      family of transcriptional regulators.
PG  - 323-36
AB  - The hedgehog (Hh) signaling pathway is crucial for pattern formation during
      metazoan development. Although originially characterized in Drosophila,
      vertebrate homologs have been identified for several, but not all, genes in the
      pathway. Analysis of mutants in Drosophila demonstrates that Suppressor of fused 
      [Su(fu)] interacts genetically with genes encoding proteins in the Hh signal
      transduction pathway, and its protein product physically interacts with two of
      the proteins in the Hh pathway. We report here the molecular cloning and
      characterization of chicken and mouse homologs of Su(fu). The chick and mouse
      proteins are 27% identical and 53% similar at the amino acid level to the
      Drosophila melanogaster and Drosophila virilis proteins. Vertebrate Su(fu) is
      widely expressed in the developing embryo with higher levels in tissues that are 
      known to be patterned by Hh signaling. The chick Su(fu) protein can physically
      interact with factors known to function in Hh signal transduction including the
      Drosophila serine/threonine kinase, Fused, and the vertebrate transcriptional
      regulators Gli1 and Gli3. This interaction may be significant for transcriptional
      regulation, as recombinant Su(fu) enhances the ability of Gli proteins to bind
      DNA in electrophoretic mobility shift assays.
CI  - Copyright 1999 Academic Press.
FAU - Pearse, R V 2nd
AU  - Pearse RV 2nd
AD  - Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston,
      Massachusetts, 02115, USA.
FAU - Collier, L S
AU  - Collier LS
FAU - Scott, M P
AU  - Scott MP
FAU - Tabin, C J
AU  - Tabin CJ
LA  - eng
GR  - Howard Hughes Medical Institute/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (GLI3 protein, Xenopus)
RN  - 0 (GLI3 protein, human)
RN  - 0 (Gli3 protein, mouse)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Oncogene Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (SUFU protein, human)
RN  - 0 (Sufu protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Xenopus Proteins)
RN  - 0 (Zinc Finger Protein GLI1)
RN  - 0 (Zinc Finger Protein Gli3)
RN  - 149291-21-4 (hh protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chickens
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - *Drosophila Proteins
MH  - Gene Expression
MH  - Hedgehog Proteins
MH  - Insect Proteins/metabolism
MH  - Kruppel-Like Transcription Factors
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - *Nerve Tissue Proteins
MH  - Oncogene Proteins/genetics/*metabolism
MH  - Peptide Fragments/metabolism
MH  - Protein Binding
MH  - Proteins/metabolism
MH  - Recombinant Proteins/metabolism
MH  - Repressor Proteins/genetics/*metabolism
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Tissue Distribution
MH  - *Trans-Activators
MH  - Transcription Factors/genetics/*metabolism
MH  - *Xenopus Proteins
MH  - Zinc Finger Protein GLI1
MH  - Zinc Finger Protein Gli3
PMC - PMC4530617
MID - HHMIMS282145
OID - NLM: HHMIMS282145
EDAT- 1999/08/06 10:00
MHDA- 2001/03/28 10:01
CRDT- 1999/08/06 10:00
PHST- 1999/08/06 10:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1999/08/06 10:00 [entrez]
AID - 10.1006/dbio.1999.9335 [doi]
AID - S0012-1606(99)99335-1 [pii]
PST - ppublish
SO  - Dev Biol. 1999 Aug 15;212(2):323-36. doi: 10.1006/dbio.1999.9335.