PMID- 10433822
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20181201
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 212
IP  - 2
DP  - 1999 Aug 15
TI  - The mouse SLIT family: secreted ligands for ROBO expressed in patterns that
      suggest a role in morphogenesis and axon guidance.
PG  - 290-306
AB  - The Slit gene encodes a secreted molecule essential for neural development in
      Drosophila embryos. Here we report the identification of three Slit homologues in
      the mouse. We demonstrate that the mouse SLIT1 protein can bind ROBO1, a
      transmembrane receptor implicated in axon guidance. Both whole-mount and section 
      in situ hybridization studies reveal unique and complementary patterns of
      expression of the three mouse Slit genes and of Robo1, both within the central
      nervous system and in other developing tissues. The complementary expression
      patterns of Slit and Robo1 and their in vitro interaction suggest a
      ligand-receptor relationship. The expression of all three Slit genes in the floor
      plate suggests that they are likely to share the same functional properties with 
      their Drosophila homologue in midline neural development and axon guidance. The
      complementary expression of Slit and Robo1 in different subdivisions of the
      somites suggests their possible function in axon pathfinding and neural crest
      cell migration. The unique expression pattern in limb and other organs indicates 
      additional potential functions of the Slit gene family.
CI  - Copyright 1999 Academic Press.
FAU - Yuan, W
AU  - Yuan W
AD  - Department of Molecular Biology and Pharmacology, Department of Anatomy and
      Neurobiology, Department of Pediatrics, Washington University School of Medicine,
      660 S. Euclid Avenue, St. Louis, Missouri, 63110, USA.
FAU - Zhou, L
AU  - Zhou L
FAU - Chen, J H
AU  - Chen JH
FAU - Wu, J Y
AU  - Wu JY
FAU - Rao, Y
AU  - Rao Y
FAU - Ornitz, D M
AU  - Ornitz DM
LA  - eng
SI  - GENBANK/AF144627
SI  - GENBANK/AF144628
SI  - GENBANK/AF144629
GR  - CA60673/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (DNA, Complementary)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Ligands)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Slit1 protein, mouse)
RN  - 0 (roundabout protein)
RN  - 0 (sli protein, Drosophila)
RN  - R6FXH13RRC (Slit homolog 2 protein)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Axons/*physiology
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - *Drosophila Proteins
MH  - Evolution, Molecular
MH  - In Situ Hybridization
MH  - Intercellular Signaling Peptides and Proteins
MH  - Ligands
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/genetics/*metabolism
MH  - Nervous System/*embryology
MH  - Protein Binding
MH  - Receptors, Immunologic/*metabolism
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
MH  - Tissue Distribution
EDAT- 1999/08/06 00:00
MHDA- 1999/08/06 00:01
CRDT- 1999/08/06 00:00
PHST- 1999/08/06 00:00 [pubmed]
PHST- 1999/08/06 00:01 [medline]
PHST- 1999/08/06 00:00 [entrez]
AID - 10.1006/dbio.1999.9371 [doi]
AID - S0012-1606(99)99371-5 [pii]
PST - ppublish
SO  - Dev Biol. 1999 Aug 15;212(2):290-306. doi: 10.1006/dbio.1999.9371.