PMID- 10433515
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20190921
IS  - 0898-6568 (Print)
IS  - 0898-6568 (Linking)
VI  - 11
IP  - 8
DP  - 1999 Aug
TI  - Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling.
PG  - 545-54
AB  - The small G proteins of the Ras family act as bimodal relays in the transfer of
      intracellular signals. This is a dynamic phenomenon involving a cascade of
      protein-protein interactions modulated by chemical modifications, structural
      rearrangements and intracellular relocalisations. Most of the small G proteins
      could be operationally defined as proteins having two conformational states, each
      of which interacts with different cellular partners. These two states are
      determined by the nature of the bound nucleotide, GDP or GTP. This capacity to
      cycle between a GDP-bound conformation and a GTP-bound conformation enables them 
      to filter, to amplify or to temporise the upstream signals that they receive.
      Thus the control of this cycle is crucial. Membrane anchoring of the proteins in 
      the Ras family is a prerequisite for their activity. Most of the proteins in the 
      Rho/Rac and Rab subfamilies of Ras proteins cycle between cytosol and membranes. 
      Then the control of membrane association/dissociation is an other important
      regulation level. This review will describe one family of crucial regulators
      acting on proteins in the Rho/Rac family-the Rho guanine nucleotide dissociation 
      inhibitors, or RhoGDIs. As yet, only three RhoGDIs have been described: RhoGDI-1,
      RhoGDI-2 (or D4/Ly-GDI) and RhoGDI-3. RhoGDI 1 and 2 are cytosolic and
      participate in the regulation of both the GDP/GTP cycle and the membrane
      association/dissociation cycle of Rho/Rac proteins. The non-cytosolic RhoGDI-3
      seems to act in a slightly different way.
FAU - Olofsson, B
AU  - Olofsson B
AD  - CNRS UPR 9063, Laboratoire d'Enzymologie et Biochimie Structurales, Gif sur
      Yvette, France. birgitta.olofsson@lebs.cnrs-gif.fr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Cell Signal
JT  - Cellular signalling
JID - 8904683
RN  - 0 (ARHGDIA protein, human)
RN  - 0 (ARHGDIB protein, human)
RN  - 0 (Guanine Nucleotide Dissociation Inhibitors)
RN  - 0 (rho Guanine Nucleotide Dissociation Inhibitor alpha)
RN  - 0 (rho Guanine Nucleotide Dissociation Inhibitor beta)
RN  - 0 (rho-Specific Guanine Nucleotide Dissociation Inhibitors)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.5.2 (rac GTP-Binding Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cytosol/metabolism
MH  - GTP-Binding Proteins/chemistry/genetics/*metabolism
MH  - *Guanine Nucleotide Dissociation Inhibitors
MH  - Humans
MH  - Molecular Sequence Data
MH  - Mutagenesis
MH  - Protein Conformation
MH  - *Signal Transduction
MH  - rac GTP-Binding Proteins
MH  - rho Guanine Nucleotide Dissociation Inhibitor alpha
MH  - rho Guanine Nucleotide Dissociation Inhibitor beta
MH  - rho-Specific Guanine Nucleotide Dissociation Inhibitors
RF  - 81
EDAT- 1999/08/05 00:00
MHDA- 1999/08/05 00:01
CRDT- 1999/08/05 00:00
PHST- 1999/08/05 00:00 [pubmed]
PHST- 1999/08/05 00:01 [medline]
PHST- 1999/08/05 00:00 [entrez]
AID - S0898-6568(98)00063-1 [pii]
AID - 10.1016/s0898-6568(98)00063-1 [doi]
PST - ppublish
SO  - Cell Signal. 1999 Aug;11(8):545-54. doi: 10.1016/s0898-6568(98)00063-1.