PMID- 10433268
OWN - NLM
STAT- MEDLINE
DCOM- 19990813
LR  - 20210218
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 23
IP  - 3
DP  - 1999 Jul
TI  - Shank, a novel family of postsynaptic density proteins that binds to the NMDA
      receptor/PSD-95/GKAP complex and cortactin.
PG  - 569-82
AB  - NMDA receptors are linked to intracellular cytoskeletal and signaling molecules
      via the PSD-95 protein complex. We report a novel family of postsynaptic density 
      (PSD) proteins, termed Shank, that binds via its PDZ domain to the C terminus of 
      PSD-95-associated protein GKAP. A ternary complex of Shank/GKAP/PSD-95 assembles 
      in heterologous cells and can be coimmunoprecipitated from rat brain. Synaptic
      localization of Shank in neurons is inhibited by a GKAP splice variant that lacks
      the Shank-binding C terminus. In addition to its PDZ domain, Shank contains a
      proline-rich region that binds to cortactin and a SAM domain that mediates
      multimerization. Shank may function as a scaffold protein in the PSD, potentially
      cross-linking NMDA receptor/PSD-95 complexes and coupling them to regulators of
      the actin cytoskeleton.
FAU - Naisbitt, S
AU  - Naisbitt S
AD  - Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts
      General Hospital and Harvard Medical School, Boston 02114, USA.
FAU - Kim, E
AU  - Kim E
FAU - Tu, J C
AU  - Tu JC
FAU - Xiao, B
AU  - Xiao B
FAU - Sala, C
AU  - Sala C
FAU - Valtschanoff, J
AU  - Valtschanoff J
FAU - Weinberg, R J
AU  - Weinberg RJ
FAU - Worley, P F
AU  - Worley PF
FAU - Sheng, M
AU  - Sheng M
LA  - eng
SI  - GENBANK/AF131951
SI  - GENBANK/AF133301
GR  - DA103009/DA/NIDA NIH HHS/United States
GR  - NS29879/NS/NINDS NIH HHS/United States
GR  - NS35050/NS/NINDS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Actins)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cortactin)
RN  - 0 (Cttn protein, rat)
RN  - 0 (Disks Large Homolog 4 Protein)
RN  - 0 (Dlg4 protein, rat)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (SAP90-PSD95 Associated Proteins)
RN  - 0 (Shank1 protein, rat)
RN  - 0 (Shank3 protein, rat)
RN  - 0 (postsynaptic density proteins)
SB  - IM
MH  - Actins/metabolism
MH  - *Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - COS Cells
MH  - Carrier Proteins/analysis/chemistry/*genetics/*metabolism
MH  - Cortactin
MH  - Cytoskeleton/chemistry/ultrastructure
MH  - Disks Large Homolog 4 Protein
MH  - Hippocampus/cytology
MH  - Intracellular Signaling Peptides and Proteins
MH  - Membrane Proteins
MH  - Microfilament Proteins/analysis/*metabolism
MH  - Microscopy, Immunoelectron
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Nerve Tissue Proteins/analysis/*metabolism
MH  - Neurons/*chemistry/cytology/metabolism
MH  - Protein Structure, Tertiary
MH  - Rabbits
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/analysis/*metabolism
MH  - SAP90-PSD95 Associated Proteins
MH  - Sequence Homology, Amino Acid
MH  - Synapses/chemistry/metabolism/ultrastructure
EDAT- 1999/08/05 00:00
MHDA- 1999/08/05 00:01
CRDT- 1999/08/05 00:00
PHST- 1999/08/05 00:00 [pubmed]
PHST- 1999/08/05 00:01 [medline]
PHST- 1999/08/05 00:00 [entrez]
AID - S0896-6273(00)80809-0 [pii]
AID - 10.1016/s0896-6273(00)80809-0 [doi]
PST - ppublish
SO  - Neuron. 1999 Jul;23(3):569-82. doi: 10.1016/s0896-6273(00)80809-0.