PMID- 10432293
OWN - NLM
STAT- MEDLINE
DCOM- 19991020
LR  - 20181113
IS  - 0264-6021 (Print)
IS  - 0264-6021 (Linking)
VI  - 342 ( Pt 1)
DP  - 1999 Aug 15
TI  - DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides.
PG  - 7-12
AB  - We have identified a novel 280 amino acid protein which contains a putative
      myristoylation site at its N-terminus followed by an Src homology (SH2) domain
      and a pleckstrin homology (PH) domain at its C-terminus. It has been termed dual 
      adaptor for phosphotyrosine and 3-phosphoinositides (DAPP1). DAPP1 is widely
      expressed and exhibits high-affinity interactions with PtdIns(3,4,5)P(3) and
      PtdIns(3,4)P(2), but not with other phospholipids tested. These observations
      predict that DAPP1 will interact with both tyrosine phosphorylated proteins and
      3-phosphoinositides and may therefore play a role in regulating the location
      and/or activity of such proteins(s) in response to agonists that elevate
      PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2).
FAU - Dowler, S
AU  - Dowler S
AD  - MRC Protein Phosphorylation Unit, Department of Biochemistry, MSI/WTB Complex,
      University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.
      sjdowler@bad.dundee.ac.uk
FAU - Currie, R A
AU  - Currie RA
FAU - Downes, C P
AU  - Downes CP
FAU - Alessi, D R
AU  - Alessi DR
LA  - eng
SI  - GENBANK/AF163254
SI  - GENBANK/AF163255
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biochem J
JT  - The Biochemical journal
JID - 2984726R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Blood Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (DAPP1 protein, human)
RN  - 0 (Dapp1 protein, mouse)
RN  - 0 (Fatty Acids)
RN  - 0 (Lipoproteins)
RN  - 0 (Phosphatidylinositol Phosphates)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (phosphatidylinositol 3,4,5-triphosphate)
RN  - 0 (phosphatidylinositol 3,4-diphosphate)
RN  - 21820-51-9 (Phosphotyrosine)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blood Proteins/chemistry/genetics/*metabolism
MH  - Carrier Proteins/chemistry/genetics/*metabolism
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Expressed Sequence Tags
MH  - *Fatty Acids
MH  - Humans
MH  - *Lipoproteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phosphatidylinositol Phosphates/chemistry/*metabolism
MH  - Phosphotyrosine/*metabolism
MH  - RNA, Messenger/analysis/genetics
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - Recombinant Fusion Proteins/chemistry/genetics/metabolism
MH  - Sequence Deletion
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Stereoisomerism
MH  - src Homology Domains/genetics/physiology
PMC - PMC1220429
EDAT- 1999/08/05 00:00
MHDA- 1999/08/05 00:01
CRDT- 1999/08/05 00:00
PHST- 1999/08/05 00:00 [pubmed]
PHST- 1999/08/05 00:01 [medline]
PHST- 1999/08/05 00:00 [entrez]
PST - ppublish
SO  - Biochem J. 1999 Aug 15;342 ( Pt 1):7-12.