PMID- 10431838
OWN - NLM
STAT- MEDLINE
DCOM- 19990826
LR  - 20191210
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 454
IP  - 3
DP  - 1999 Jul 9
TI  - PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins.
PG  - 356-62
AB  - The PACSIN-related proteins are cytoplasmic adapter proteins with a common
      arrangement of domains and conserved regions. Here we report the cloning,
      sequencing, and expression of PACSIN 2, a novel member of the PACSIN protein
      family and accordingly rename the original PACSIN to PACSIN 1. The sequences of
      the murine and human cDNAs reveal an open reading frame encoding a putative
      protein of 486 residues. Despite its high sequence similarity to PACSIN 1, PACSIN
      2 is encoded by distinct transcripts in human and mouse, in particular displaying
      a ubiquitous expression pattern. Immunofluorescence microscopy of PACSIN
      2-transfected NIH3T3 fibroblasts reveal a broad, vesicle-like cytoplasmic
      staining. In contrast to FAP52, another PACSIN-related protein derived from
      chicken brain, PACSIN 2 could not be detected at focal contacts. Taken together, 
      these findings suggest that PACSIN 2 is a novel PACSIN isoform with similar
      domain and motif arrangement, but an unrestricted expression pattern, which may
      participate in the organization of the actin cytoskeleton and the regulation of
      vesicular traffic.
FAU - Ritter, B
AU  - Ritter B
AD  - Institut fur Biochemie II, Medizinische Fakultat, Universitat zu Koln, Cologne,
      Germany.
FAU - Modregger, J
AU  - Modregger J
FAU - Paulsson, M
AU  - Paulsson M
FAU - Plomann, M
AU  - Plomann M
LA  - eng
SI  - GENBANK/AF128535
SI  - GENBANK/AF128536
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (PACSIN2 protein, human)
RN  - 0 (Pacsin2 protein, mouse)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proteins)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Cytoplasm/metabolism
MH  - Cytoskeletal Proteins
MH  - DNA, Complementary/genetics/isolation & purification
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phosphoproteins/*genetics/metabolism
MH  - Proteins/*genetics/metabolism
MH  - Sequence Alignment
MH  - src Homology Domains
EDAT- 1999/08/04 00:00
MHDA- 1999/08/04 00:01
CRDT- 1999/08/04 00:00
PHST- 1999/08/04 00:00 [pubmed]
PHST- 1999/08/04 00:01 [medline]
PHST- 1999/08/04 00:00 [entrez]
AID - S0014-5793(99)00830-3 [pii]
AID - 10.1016/s0014-5793(99)00830-3 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Jul 9;454(3):356-62. doi: 10.1016/s0014-5793(99)00830-3.