PMID- 10431818
OWN - NLM
STAT- MEDLINE
DCOM- 19990826
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 454
IP  - 3
DP  - 1999 Jul 9
TI  - A family of structurally related RING finger proteins interacts specifically with
      the ubiquitin-conjugating enzyme UbcM4.
PG  - 257-61
AB  - The ubiquitin-conjugating enzyme UbcM4 was previously shown to be necessary for
      normal mouse development. As a first step in identifying target proteins or
      proteins involved in the specificity of UbcM4-mediated ubiquitylation, we have
      isolated seven cDNAs encoding proteins that specifically interact with UbcM4 but 
      with none of the other Ubcs tested. This interaction was observed in yeast as
      well as in mammalian cells. With one exception, all UbcM4-interacting proteins
      (UIPs) belong to a family of proteins that contain a RING finger motif. As they
      are structurally related to RING finger proteins that have recently been shown to
      play an essential role in protein ubiquitylation and degradation, the possibility
      is discussed that UIPs are involved in the specific recognition of substrate
      proteins of UbcM4.
FAU - Martinez-Noel, G
AU  - Martinez-Noel G
AD  - Heinrich-Pette-Institut fur Experimentelle Virologie und Immunologie an der
      Universitat Hamburg, Germany.
FAU - Niedenthal, R
AU  - Niedenthal R
FAU - Tamura, T
AU  - Tamura T
FAU - Harbers, K
AU  - Harbers K
LA  - eng
SI  - GENBANK/AF124663
SI  - GENBANK/AF124664
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (DNA-Binding Proteins)
RN  - EC 2.3.2.23 (Ube2l3 protein, mouse)
RN  - EC 2.3.2.23 (Ubiquitin-Conjugating Enzymes)
RN  - EC 6.- (Ligases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - DNA-Binding Proteins/*metabolism
MH  - Ligases/*metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Protein Binding
MH  - Saccharomyces cerevisiae
MH  - Sequence Alignment
MH  - Substrate Specificity
MH  - *Ubiquitin-Conjugating Enzymes
MH  - Zinc Fingers
EDAT- 1999/08/04 00:00
MHDA- 1999/08/04 00:01
CRDT- 1999/08/04 00:00
PHST- 1999/08/04 00:00 [pubmed]
PHST- 1999/08/04 00:01 [medline]
PHST- 1999/08/04 00:00 [entrez]
AID - S0014579399008236 [pii]
AID - 10.1016/s0014-5793(99)00823-6 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Jul 9;454(3):257-61. doi: 10.1016/s0014-5793(99)00823-6.