PMID- 10431242
OWN - NLM
STAT- MEDLINE
DCOM- 19990826
LR  - 20081121
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 22
IP  - 4
DP  - 1999 Aug
TI  - Involvement of a novel Tnf receptor homologue in hair follicle induction.
PG  - 370-4
AB  - Although inductive interactions are known to be essential for specification of
      cell fate in many vertebrate tissues, the signals and receptors responsible for
      transmitting this information remain largely unidentified. Mice with mutations in
      the downless (dl) gene have defects in hair follicle induction, lack sweat glands
      and have malformed teeth. These structures originate as ectodermal placodes,
      which invaginate into the underlying mesenchyme and differentiate to form
      specific organs. Positional cloning of the dl gene began with identification of
      the transgenic family OVE1. One branch of the family, dl(OVE1B), carries an
      approximately 600-kb deletion at the dl locus caused by transgene integration.
      The mutated locus has been physically mapped in this family, and a 200-kb mouse
      YAC clone, YAC D9, has been identified and shown to rescue the dl phenotype in
      the spontaneous dl(Jackson) (dl(J), recessive) and Dl(sleek) (Dl(slk), dominant
      negative) mutants. Here we report the positional cloning of the dl gene, which
      encodes a novel member of the tumour necrosis factor (Tnf) receptor (Tnfr)
      family. The mutant phenotype and dl expression pattern suggests that this gene
      encodes a receptor that specifies hair follicle fate. Its ligand is likely to be 
      the product of the tabby (Ta) gene, as Ta mutants have a phenotype identical to
      that of dl mutants and Ta encodes a Tnf-like protein.
FAU - Headon, D J
AU  - Headon DJ
AD  - Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030,
      USA.
FAU - Overbeek, P A
AU  - Overbeek PA
LA  - eng
SI  - GENBANK/AF160502
SI  - GENBANK/X56848
SI  - GENBANK/X76290
SI  - SWISSPROT/P07174
SI  - SWISSPROT/P25118
SI  - SWISSPROT/P25446
GR  - AR45316/AR/NIAMS NIH HHS/United States
GR  - HL49953/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (BMP4 protein, human)
RN  - 0 (Bmp4 protein, mouse)
RN  - 0 (Bone Morphogenetic Protein 4)
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (EDA protein, human)
RN  - 0 (EDAR protein, human)
RN  - 0 (Ectodysplasins)
RN  - 0 (Eda protein, mouse)
RN  - 0 (Edar Receptor)
RN  - 0 (Edar protein, mouse)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Ectodysplasin)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Trans-Activators)
SB  - IM
CIN - Nat Genet. 1999 Aug;22(4):315-6. PMID: 10431226
MH  - Amino Acid Sequence
MH  - Animals
MH  - Bone Morphogenetic Protein 4
MH  - Bone Morphogenetic Proteins/analysis
MH  - Cloning, Molecular
MH  - Ectodysplasins
MH  - Edar Receptor
MH  - Hair Follicle/embryology/*physiology
MH  - Hedgehog Proteins
MH  - Humans
MH  - Membrane Proteins/analysis/*genetics/*physiology
MH  - Mice
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Phenotype
MH  - Proteins/analysis
MH  - Receptors, Ectodysplasin
MH  - Receptors, Tumor Necrosis Factor/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Skin/anatomy & histology/embryology
MH  - *Trans-Activators
EDAT- 1999/08/04 10:00
MHDA- 2001/03/23 10:01
CRDT- 1999/08/04 10:00
PHST- 1999/08/04 10:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/08/04 10:00 [entrez]
AID - 10.1038/11943 [doi]
PST - ppublish
SO  - Nat Genet. 1999 Aug;22(4):370-4. doi: 10.1038/11943.