PMID- 10430503
OWN - NLM
STAT- MEDLINE
DCOM- 19991008
LR  - 20191210
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 93
IP  - 1
DP  - 1999
TI  - Developmental localization of semaphorin H messenger RNA acting as a collapsing
      factor on sensory axons in the mouse brain.
PG  - 401-8
AB  - Semaphorins/collapsins, a family of genes with a semaphorin domain conserved from
      insects through to mammals, are believed to be involved in axon guidance during
      neuronal development. We report the expression patterns of mouse semaphorin
      messenger RNAs. Among secreted semaphorins, mouse semaphorin H is structurally
      most similar to semaphorin III/D, the first semaphorin identified as a collapsing
      factor for sensory axons. However, its expression patterns apparently differ from
      those of semaphorin III/D. The messenger RNAs are distributed in the brain widely
      but unevenly during development, in particular, in the main olfactory bulb,
      hippocampus and pontine nucleus. In the trunk, the expression level is high in
      mesodermal tissues surrounding the dorsal root ganglia, while it is low in the
      spinal cord. Moreover, we examined whether this molecule has activity to collapse
      growth cones of sensory neurons, as well as semaphorin III/D. Mouse semaphorin H 
      collapsed growth cones of sensory neurons of the dorsal root ganglion in a
      dose-dependent manner, and anti-neuropilin antibodies inhibited this activity.
      Taken together, these results suggest that mouse semaphorin H can function as a
      chemorepellent to guide sensory peripheral nerves, most likely via neuropilin as 
      a receptor.
FAU - Miyazaki, N
AU  - Miyazaki N
AD  - School of Allied Health Sciences, Department of Otorhinolaryngology, Osaka
      University, Faculty of Medicine, Suita-shi, Japan.
FAU - Furuyama, T
AU  - Furuyama T
FAU - Sakai, T
AU  - Sakai T
FAU - Fujioka, S
AU  - Fujioka S
FAU - Mori, T
AU  - Mori T
FAU - Ohoka, Y
AU  - Ohoka Y
FAU - Takeda, N
AU  - Takeda N
FAU - Kubo, T
AU  - Kubo T
FAU - Inagaki, S
AU  - Inagaki S
LA  - eng
SI  - GENBANK/AF034744
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Antigens, CD)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Lipoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (SEMA7A protein, human)
RN  - 0 (Sema3e protein, mouse)
RN  - 0 (Sema7a protein, mouse)
RN  - 0 (Semaphorins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Antigens, CD
MH  - Axons/*physiology/ultrastructure
MH  - Blotting, Northern
MH  - Brain/*cytology/*growth & development
MH  - Brain Chemistry/genetics
MH  - Chick Embryo
MH  - Cytoskeletal Proteins
MH  - GPI-Linked Proteins
MH  - Ganglia, Spinal/cytology/ultrastructure
MH  - Genetic Vectors
MH  - Glycoproteins/*biosynthesis/genetics
MH  - Growth Cones/physiology/ultrastructure
MH  - Humans
MH  - Lipoproteins/*biosynthesis/genetics
MH  - Membrane Proteins/*biosynthesis
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/*biosynthesis
MH  - Neurons, Afferent/*physiology/ultrastructure
MH  - RNA, Messenger/*biosynthesis/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - *Semaphorins
MH  - Transfection
EDAT- 1999/08/03 00:00
MHDA- 1999/08/03 00:01
CRDT- 1999/08/03 00:00
PHST- 1999/08/03 00:00 [pubmed]
PHST- 1999/08/03 00:01 [medline]
PHST- 1999/08/03 00:00 [entrez]
AID - S0306-4522(99)00134-7 [pii]
AID - 10.1016/s0306-4522(99)00134-7 [doi]
PST - ppublish
SO  - Neuroscience. 1999;93(1):401-8. doi: 10.1016/s0306-4522(99)00134-7.