PMID- 10429951
OWN - NLM
STAT- MEDLINE
DCOM- 19991026
LR  - 20191103
IS  - 0945-053X (Print)
IS  - 0945-053X (Linking)
VI  - 18
IP  - 3
DP  - 1999 Jun
TI  - Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3, their
      phylogenetic analysis and tissue-specific expression in the mouse.
PG  - 325-9
AB  - We report on the isolation and characterization of cDNA clones for mouse lysyl
      hydroxylases 1, 2 and 3 (LH1, LH2, LH3). Phylogenetic analysis using nine lysyl
      hydroxylase sequences from five species indicates that the isoforms are derived
      from an ancestral gene by two duplication events, isoforms 1 and 2 being more
      closely related and having resulted from a more recent duplication than isoform
      3. Expression of the isoforms is highly regulated in adult mouse tissues. LH1 is 
      strongly expressed in the liver, heart, lung, skeletal muscle and kidney tissue, 
      LH2 expression is high in the heart, lung, kidney, eye, ovary and placenta,
      whereas LH3 expression is high in the heart, lung, liver and testis tissue.
FAU - Ruotsalainen, H
AU  - Ruotsalainen H
AD  - Department of Biochemistry, University of Oulu, Linnanmaa, Finland.
FAU - Sipila, L
AU  - Sipila L
FAU - Kerkela, E
AU  - Kerkela E
FAU - Pospiech, H
AU  - Pospiech H
FAU - Myllyla, R
AU  - Myllyla R
LA  - eng
SI  - GENBANK/AF046782
SI  - GENBANK/AF046783
SI  - GENBANK/AF080572
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Matrix Biol
JT  - Matrix biology : journal of the International Society for Matrix Biology
JID - 9432592
RN  - 0 (3' Untranslated Regions)
RN  - 0 (DNA, Complementary)
RN  - 0 (Isoenzymes)
RN  - EC 1.14.11.4 (Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase)
RN  - EC 1.14.11.4 (lysyl hydroxylase 2, mouse)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Amino Acid Sequence
MH  - Animals
MH  - DNA, Complementary
MH  - Humans
MH  - Isoenzymes/classification/genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/classification/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
EDAT- 1999/08/03 00:00
MHDA- 1999/08/03 00:01
CRDT- 1999/08/03 00:00
PHST- 1999/08/03 00:00 [pubmed]
PHST- 1999/08/03 00:01 [medline]
PHST- 1999/08/03 00:00 [entrez]
AID - S0945-053X(99)00016-5 [pii]
AID - 10.1016/s0945-053x(99)00016-5 [doi]
PST - ppublish
SO  - Matrix Biol. 1999 Jun;18(3):325-9. doi: 10.1016/s0945-053x(99)00016-5.