PMID- 10429950
OWN - NLM
STAT- MEDLINE
DCOM- 19991026
LR  - 20191210
IS  - 0945-053X (Print)
IS  - 0945-053X (Linking)
VI  - 18
IP  - 3
DP  - 1999 Jun
TI  - cDNA cloning, characterization and chromosome mapping of Crtap encoding the mouse
      cartilage associated protein.
PG  - 319-24
AB  - Recently we have isolated and characterized a cDNA coding for a novel
      developmentally regulated chick embryo protein, cartilage associated protein
      (CASP). Here we describe the isolation and characterization of the cDNAs coding
      for the mouse CASP. Comparison of the mammalian putative protein sequence with
      the chick sequence shows a very high identity overall (51%); in particular the
      chick protein is homologous to the half amino terminus of the mouse protein.
      Furthermore, the comparison of the CASP cDNA sequence with sequences of the
      genebank database confirms our hypothesis that the CASP genes belong to a novel
      family that also includes genes encoding for some nuclear antigens. In all mouse 
      tissues examined three CASP mRNAs species are detected, whereas in chick tissues 
      a single mRNA is present. Immunohistochemistry studies show that the protein is
      expressed in all mouse embryonic cartilages. The mouse cartilage associated
      protein gene (Crtap) was assigned to chromosome 9F3-F4 by fluorescence in situ
      hybridization.
FAU - Morello, R
AU  - Morello R
AD  - Istituto Nazional per la Ricerca sul Cancro, Centro di Biotecnologie Avanzate,
      Genova, Italy.
FAU - Tonachini, L
AU  - Tonachini L
FAU - Monticone, M
AU  - Monticone M
FAU - Viggiano, L
AU  - Viggiano L
FAU - Rocchi, M
AU  - Rocchi M
FAU - Cancedda, R
AU  - Cancedda R
FAU - Castagnola, P
AU  - Castagnola P
LA  - eng
SI  - GENBANK/AJ006469
GR  - E.0672/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Matrix Biol
JT  - Matrix biology : journal of the International Society for Matrix Biology
JID - 9432592
RN  - 0 (Crtap protein, mouse)
RN  - 0 (DNA, Complementary)
RN  - 0 (Molecular Chaperones)
RN  - 0 (Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cartilage, Articular/embryology/*metabolism
MH  - Chick Embryo
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Embryonic and Fetal Development
MH  - Gene Expression
MH  - Mice
MH  - Molecular Chaperones
MH  - Molecular Sequence Data
MH  - Proteins/*genetics
MH  - Sequence Homology, Amino Acid
EDAT- 1999/08/03 00:00
MHDA- 1999/08/03 00:01
CRDT- 1999/08/03 00:00
PHST- 1999/08/03 00:00 [pubmed]
PHST- 1999/08/03 00:01 [medline]
PHST- 1999/08/03 00:00 [entrez]
AID - S0945-053X(99)00002-5 [pii]
AID - 10.1016/s0945-053x(99)00002-5 [doi]
PST - ppublish
SO  - Matrix Biol. 1999 Jun;18(3):319-24. doi: 10.1016/s0945-053x(99)00002-5.