PMID- 10429654
OWN - NLM
STAT- MEDLINE
DCOM- 19990812
LR  - 20211203
IS  - 0910-5050 (Print)
IS  - 0910-5050 (Linking)
VI  - 90
IP  - 6
DP  - 1999 Jun
TI  - Mutational analysis of STK11 gene in ovarian carcinomas.
PG  - 629-32
AB  - Recently STK11, the causative gene of Peutz-Jeghers syndrome (PJS) was identified
      on chromosome 19p13.3. PJS is often accompanied by several malignancies,
      including breast tumor, adenoma malignum of the uterine cervix, and ovarian
      tumor. To investigate the involvement of STK11 gene in the development of ovarian
      carcinomas, we analyzed 30 ovarian carcinomas for loss of heterozygosity (LOH)
      and STK11 gene mutations. We found one missense mutation (codon 281, Pro to Leu) 
      with heterozygous and somatic status. This mutation occurred at codon 281, which 
      lies within the mutational hot spot (codon 279-281) of STK11 gene previously
      reported in PJS. We also detected LOH in 2 (11%) of 19 informative ovarian
      carcinomas. Our results suggest that mutations of the STK11 gene may play a
      limited role in the development of ovarian carcinomas.
FAU - Nishioka, Y
AU  - Nishioka Y
AD  - Department of Obstetrics and Gynecology, Sapporo Medical University School of
      Medicine, Hokkaido.
FAU - Kobayashi, K
AU  - Kobayashi K
FAU - Sagae, S
AU  - Sagae S
FAU - Sugimura, M
AU  - Sugimura M
FAU - Ishioka, S
AU  - Ishioka S
FAU - Nagata, M
AU  - Nagata M
FAU - Terasawa, K
AU  - Terasawa K
FAU - Tokino, T
AU  - Tokino T
FAU - Kudo, R
AU  - Kudo R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (STK11 protein, human)
RN  - EC 2.7.11.3 (AMP-Activated Protein Kinase Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinase Kinases
MH  - Female
MH  - Humans
MH  - *Loss of Heterozygosity
MH  - *Mutation
MH  - Ovarian Neoplasms/*genetics
MH  - Peutz-Jeghers Syndrome/*genetics
MH  - Protein Serine-Threonine Kinases/genetics
PMC - PMC5926111
EDAT- 1999/08/03 00:00
MHDA- 1999/08/03 00:01
CRDT- 1999/08/03 00:00
PHST- 1999/08/03 00:00 [pubmed]
PHST- 1999/08/03 00:01 [medline]
PHST- 1999/08/03 00:00 [entrez]
AID - S0910505099801276 [pii]
AID - 10.1111/j.1349-7006.1999.tb00793.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 1999 Jun;90(6):629-32. doi: 10.1111/j.1349-7006.1999.tb00793.x.