PMID- 10428823
OWN - NLM
STAT- MEDLINE
DCOM- 19990902
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 32
DP  - 1999 Aug 6
TI  - DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and
      balloon-injured arteries.
PG  - 22476-83
AB  - We have identified and characterized mouse, rat, and human cDNAs that encode a
      novel secreted protein of 448 amino acids named DANCE (developmental arteries and
      neural crest epidermal growth factor (EGF)-like). DANCE contains six
      calcium-binding EGF-like domains, one of which includes an RGD motif.
      Overexpression studies of recombinant DANCE protein document that DANCE is a
      secreted 66-kDa protein. DANCE and recently described protein S1-5 comprise a new
      EGF-like protein family. The human DANCE gene was mapped at chromosome 14q32.1.
      DANCE mRNA is mainly expressed in heart, ovary, and colon in adult human tissues.
      Expression profile analysis by in situ hybridization revealed prominent DANCE
      expression in developing arteries. DANCE is also expressed in neural crest cell
      derivatives, endocardial cushion tissue, and several other mesenchymal tissues.
      In adult vessels, DANCE expression is largely diminished but is reinduced in
      balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular 
      smooth muscle cells and endothelial cells that lose their ability to proliferate 
      in late stage of injury. DANCE protein was shown to promote adhesion of
      endothelial cells through interaction of integrins and the RGD motif of DANCE.
      DANCE is thus a novel vascular ligand for integrin receptors and may play a role 
      in vascular development and remodeling.
FAU - Nakamura, T
AU  - Nakamura T
AD  - Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Sakyo-ku,
      Kyoto 606, Japan.
FAU - Ruiz-Lozano, P
AU  - Ruiz-Lozano P
FAU - Lindner, V
AU  - Lindner V
FAU - Yabe, D
AU  - Yabe D
FAU - Taniwaki, M
AU  - Taniwaki M
FAU - Furukawa, Y
AU  - Furukawa Y
FAU - Kobuke, K
AU  - Kobuke K
FAU - Tashiro, K
AU  - Tashiro K
FAU - Lu, Z
AU  - Lu Z
FAU - Andon, N L
AU  - Andon NL
FAU - Schaub, R
AU  - Schaub R
FAU - Matsumori, A
AU  - Matsumori A
FAU - Sasayama, S
AU  - Sasayama S
FAU - Chien, K R
AU  - Chien KR
FAU - Honjo, T
AU  - Honjo T
LA  - eng
SI  - GENBANK/AF112151
SI  - GENBANK/AF112152
SI  - GENBANK/AF112153
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA, Complementary)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (FBLN5 protein, human)
RN  - 0 (Fbln5 protein, mouse)
RN  - 0 (Fbln5 protein, rat)
RN  - 0 (Integrins)
RN  - 0 (Oligopeptides)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 78VO7F77PN (arginyl-glycyl-aspartic acid)
SB  - IM
MH  - Amino Acid Sequence
MH  - Angioplasty, Balloon/*adverse effects
MH  - Animals
MH  - Arteries/embryology/*metabolism/pathology
MH  - Arteriosclerosis/*metabolism
MH  - Base Sequence
MH  - Cell Adhesion
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 14
MH  - Cloning, Molecular/methods
MH  - DNA, Complementary/genetics
MH  - Dose-Response Relationship, Drug
MH  - *Extracellular Matrix Proteins
MH  - Gene Library
MH  - Heart/embryology
MH  - Humans
MH  - In Situ Hybridization
MH  - Integrins/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - *Oligopeptides
MH  - RNA, Messenger/isolation & purification
MH  - Rats
MH  - Recombinant Proteins/*genetics/*metabolism/pharmacology
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
EDAT- 1999/07/31 00:00
MHDA- 1999/07/31 00:01
CRDT- 1999/07/31 00:00
PHST- 1999/07/31 00:00 [pubmed]
PHST- 1999/07/31 00:01 [medline]
PHST- 1999/07/31 00:00 [entrez]
AID - 10.1074/jbc.274.32.22476 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Aug 6;274(32):22476-83. doi: 10.1074/jbc.274.32.22476.