PMID- 10426996
OWN - NLM
STAT- MEDLINE
DCOM- 19990816
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 285
IP  - 5428
DP  - 1999 Jul 30
TI  - Cell activation and apoptosis by bacterial lipoproteins through toll-like
      receptor-2.
PG  - 736-9
AB  - Apoptosis is implicated in the generation and resolution of inflammation in
      response to bacterial pathogens. All bacterial pathogens produce lipoproteins
      (BLPs), which trigger the innate immune response. BLPs were found to induce
      apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2).
      BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2. 
      In addition, BLPs stimulated nuclear factor-kappaB, a transcriptional activator
      of multiple host defense genes, and activated the respiratory burst through
      hTLR2. Thus, hTLR2 is a molecular link between microbial products, apoptosis, and
      host defense mechanisms.
FAU - Aliprantis, A O
AU  - Aliprantis AO
AD  - Skirball Institute and Department of Microbiology, New York University School of 
      Medicine, 540 First Avenue, New York, NY 10016, USA.
FAU - Yang, R B
AU  - Yang RB
FAU - Mark, M R
AU  - Mark MR
FAU - Suggett, S
AU  - Suggett S
FAU - Devaux, B
AU  - Devaux B
FAU - Radolf, J D
AU  - Radolf JD
FAU - Klimpel, G R
AU  - Klimpel GR
FAU - Godowski, P
AU  - Godowski P
FAU - Zychlinsky, A
AU  - Zychlinsky A
LA  - eng
GR  - AI 37720-04/AI/NIAID NIH HHS/United States
GR  - AI-38894/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Bacterial Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Lipoproteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Protein Synthesis Inhibitors)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (TLR2 protein, human)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptors)
RN  - 98600C0908 (Cycloheximide)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - *Apoptosis
MH  - Bacterial Proteins/metabolism/*pharmacology
MH  - Cell Line/metabolism
MH  - Cycloheximide/pharmacology
MH  - Cytotoxicity, Immunologic
MH  - *Drosophila Proteins
MH  - Genes, Reporter
MH  - Humans
MH  - Lipopolysaccharide Receptors/analysis
MH  - Lipopolysaccharides/immunology
MH  - Lipoproteins/metabolism/*pharmacology
MH  - Membrane Glycoproteins/immunology/*metabolism
MH  - Monocytes/*cytology/immunology/metabolism
MH  - NF-kappa B/metabolism
MH  - Protein Synthesis Inhibitors/pharmacology
MH  - Reactive Oxygen Species/metabolism
MH  - Receptors, Cell Surface/immunology/*metabolism
MH  - Signal Transduction
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - Toll-Like Receptor 2
MH  - Toll-Like Receptors
MH  - Transfection
MH  - Tumor Cells, Cultured
EDAT- 1999/07/31 00:00
MHDA- 1999/07/31 00:01
CRDT- 1999/07/31 00:00
PHST- 1999/07/31 00:00 [pubmed]
PHST- 1999/07/31 00:01 [medline]
PHST- 1999/07/31 00:00 [entrez]
AID - 7716 [pii]
AID - 10.1126/science.285.5428.736 [doi]
PST - ppublish
SO  - Science. 1999 Jul 30;285(5428):736-9. doi: 10.1126/science.285.5428.736.