PMID- 10426994
OWN - NLM
STAT- MEDLINE
DCOM- 19990816
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 285
IP  - 5428
DP  - 1999 Jul 30
TI  - An activating immunoreceptor complex formed by NKG2D and DAP10.
PG  - 730-2
AB  - Many immune receptors are composed of separate ligand-binding and
      signal-transducing subunits. In natural killer (NK) and T cells, DAP10 was
      identified as a cell surface adaptor protein in an activating receptor complex
      with NKG2D, a receptor for the stress-inducible and tumor-associated major
      histocompatibility complex molecule MICA. Within the DAP10 cytoplasmic domain, an
      Src homology 2 (SH2) domain-binding site was capable of recruiting the p85
      subunit of the phosphatidylinositol 3-kinase (PI 3-kinase), providing for
      NKG2D-dependent signal transduction. Thus, NKG2D-DAP10 receptor complexes may
      activate NK and T cell responses against MICA-bearing tumors.
FAU - Wu, J
AU  - Wu J
AD  - DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA.
FAU - Song, Y
AU  - Song Y
FAU - Bakker, A B
AU  - Bakker AB
FAU - Bauer, S
AU  - Bauer S
FAU - Spies, T
AU  - Spies T
FAU - Lanier, L L
AU  - Lanier LL
FAU - Phillips, J H
AU  - Phillips JH
LA  - eng
SI  - GENBANK/AF072844
SI  - GENBANK/AF072845
SI  - GENBANK/AF072846
SI  - GENBANK/AF122904
SI  - GENBANK/AF122905
GR  - AI30581/AI/NIAID NIH HHS/United States
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (HCST protein, human)
RN  - 0 (Hcst protein, mouse)
RN  - 0 (KLRK1 protein, human)
RN  - 0 (Klrk1 protein, mouse)
RN  - 0 (Ligands)
RN  - 0 (Membrane Proteins)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily K)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Natural Killer Cell)
RN  - 21820-51-9 (Phosphotyrosine)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
SB  - IM
CON - Science. 1999 Jul 30;285(5428):645, 647. PMID: 10454908
MH  - Amino Acid Sequence
MH  - Animals
MH  - Binding Sites
MH  - Cell Line
MH  - Cytotoxicity, Immunologic
MH  - Humans
MH  - Killer Cells, Natural/*immunology/metabolism
MH  - Ligands
MH  - *Lymphocyte Activation
MH  - Membrane Proteins/chemistry/genetics/*metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - NK Cell Lectin-Like Receptor Subfamily K
MH  - Neoplasms/immunology
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phosphorylation
MH  - Phosphotyrosine/metabolism
MH  - Receptors, Immunologic/chemistry/genetics/*metabolism
MH  - Receptors, Natural Killer Cell
MH  - Signal Transduction
MH  - T-Lymphocytes/*immunology/metabolism
MH  - Tumor Cells, Cultured
MH  - src Homology Domains
EDAT- 1999/07/31 00:00
MHDA- 1999/07/31 00:01
CRDT- 1999/07/31 00:00
PHST- 1999/07/31 00:00 [pubmed]
PHST- 1999/07/31 00:01 [medline]
PHST- 1999/07/31 00:00 [entrez]
AID - 7709 [pii]
AID - 10.1126/science.285.5428.730 [doi]
PST - ppublish
SO  - Science. 1999 Jul 30;285(5428):730-2. doi: 10.1126/science.285.5428.730.