PMID- 10426993
OWN - NLM
STAT- MEDLINE
DCOM- 19990816
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 285
IP  - 5428
DP  - 1999 Jul 30
TI  - Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible
      MICA.
PG  - 727-9
AB  - Stress-inducible MICA, a distant homolog of major histocompatibility complex
      (MHC) class I, functions as an antigen for gammadelta T cells and is frequently
      expressed in epithelial tumors. A receptor for MICA was detected on most
      gammadelta T cells, CD8+ alphabeta T cells, and natural killer (NK) cells and was
      identified as NKG2D. Effector cells from all these subsets could be stimulated by
      ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of
      gammadelta T cells and NK cells against transfectants and epithelial tumor cells 
      expressing MICA. These results define an activating immunoreceptor-MHC ligand
      interaction that may promote antitumor NK and T cell responses.
FAU - Bauer, S
AU  - Bauer S
AD  - Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview
      Avenue North, Seattle, WA 98109, USA.
FAU - Groh, V
AU  - Groh V
FAU - Wu, J
AU  - Wu J
FAU - Steinle, A
AU  - Steinle A
FAU - Phillips, J H
AU  - Phillips JH
FAU - Lanier, L L
AU  - Lanier LL
FAU - Spies, T
AU  - Spies T
LA  - eng
GR  - P01 CA18221/CA/NCI NIH HHS/United States
GR  - R01 AI30581/AI/NIAID NIH HHS/United States
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (HCST protein, human)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (KLRK1 protein, human)
RN  - 0 (Ligands)
RN  - 0 (MHC class I-related chain A)
RN  - 0 (Membrane Proteins)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily K)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Natural Killer Cell)
SB  - IM
CON - Science. 1999 Jul 30;285(5428):645, 647. PMID: 10454908
MH  - Cytotoxicity, Immunologic
MH  - Histocompatibility Antigens Class I/*immunology/metabolism
MH  - Humans
MH  - Jurkat Cells
MH  - Killer Cells, Natural/*immunology
MH  - Ligands
MH  - *Lymphocyte Activation
MH  - Lymphocyte Subsets/immunology
MH  - Membrane Proteins/metabolism
MH  - NK Cell Lectin-Like Receptor Subfamily K
MH  - Receptors, Antigen, T-Cell, gamma-delta/immunology
MH  - Receptors, Immunologic/chemistry/genetics/*immunology/metabolism
MH  - Receptors, Natural Killer Cell
MH  - Signal Transduction
MH  - T-Lymphocytes/*immunology
MH  - Transfection
MH  - Tumor Cells, Cultured
EDAT- 1999/07/31 00:00
MHDA- 1999/07/31 00:01
CRDT- 1999/07/31 00:00
PHST- 1999/07/31 00:00 [pubmed]
PHST- 1999/07/31 00:01 [medline]
PHST- 1999/07/31 00:00 [entrez]
AID - 7717 [pii]
AID - 10.1126/science.285.5428.727 [doi]
PST - ppublish
SO  - Science. 1999 Jul 30;285(5428):727-9. doi: 10.1126/science.285.5428.727.