PMID- 10425712
OWN - NLM
STAT- MEDLINE
DCOM- 19991103
LR  - 20190915
IS  - 1096-4959 (Print)
IS  - 1096-4959 (Linking)
VI  - 123
IP  - 1
DP  - 1999 May
TI  - Rat and human membrane dipeptidase: tissue distribution and developmental
      changes.
PG  - 53-8
AB  - Distribution and developmental changes in membrane dipeptidase activity were
      examined in rat and human tissues. The activity to hydrolyze glycyl-D-alanine in 
      rat and human tissues was completely or almost completely inhibited by 5 mM
      cilastatin, suggesting that the activity was due to membrane dipeptidase and that
      the contribution of leucine aminopeptidase to the activity was minor. In
      8-week-old rats, the activity was high in lung, kidney, pancreas and testis, and 
      in each pooled sample of ileal mucosa, duodenal mucosa, jejunal mucosa and
      adrenal mucosa. A low activity was found in spleen, liver, serum and heart. The
      activity in lung, kidney, adrenal and intestinal mucosa increased up to the age
      of 5 or 8 weeks, while that in pancreas, testis and spleen reached a maximal
      level at around 3 weeks and declined thereafter. The distribution profile of the 
      enzyme in postmortem tissues of adult humans was similar to that in rat, except
      for an extremely low activity in lung. The enzyme was also found in serum and
      urine from healthy volunteers. In urine, the activity was significantly
      correlated to the creatinine content. No clear dependence of the activity on
      gender or age was observed in urine and serum.
FAU - Kera, Y
AU  - Kera Y
AD  - Department of Environmental Systems Engineering, Nagaoka University of
      Technology, Niigata, Japan.
FAU - Liu, Z
AU  - Liu Z
FAU - Matsumoto, T
AU  - Matsumoto T
FAU - Sorimachi, Y
AU  - Sorimachi Y
FAU - Nagasaki, H
AU  - Nagasaki H
FAU - Yamada, R H
AU  - Yamada RH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Comp Biochem Physiol B Biochem Mol Biol
JT  - Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
JID - 9516061
RN  - 0 (Dipeptides)
RN  - 0 (Enzyme Inhibitors)
RN  - 141A6AMN38 (Cilastatin)
RN  - EC 3.4.13.- (Dipeptidases)
RN  - EC 3.4.13.18 (dipeptidase)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Cell Membrane/*enzymology
MH  - Cilastatin/pharmacology
MH  - Dipeptidases/blood/*metabolism/urine
MH  - Dipeptides/metabolism
MH  - Enzyme Inhibitors/pharmacology
MH  - Female
MH  - Humans
MH  - Male
MH  - Postmortem Changes
MH  - Rats
MH  - Rats, Wistar
EDAT- 1999/07/30 00:00
MHDA- 1999/07/30 00:01
CRDT- 1999/07/30 00:00
PHST- 1999/07/30 00:00 [pubmed]
PHST- 1999/07/30 00:01 [medline]
PHST- 1999/07/30 00:00 [entrez]
AID - 10.1016/s0305-0491(99)00039-5 [doi]
PST - ppublish
SO  - Comp Biochem Physiol B Biochem Mol Biol. 1999 May;123(1):53-8. doi:
      10.1016/s0305-0491(99)00039-5.