PMID- 10425206
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20181201
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 261
IP  - 2
DP  - 1999 Aug 2
TI  - PPARgamma activation induces the expression of the adipocyte fatty acid binding
      protein gene in human monocytes.
PG  - 456-8
AB  - The peroxisome-proliferator activated receptor gamma (PPARgamma), a member of the
      nuclear receptor superfamily of ligand activated transcription factors, plays a
      key role in the anti-diabetic actions of the thiazolidinediones (TZDs). PPARgamma
      induces the expression of many genes involved in lipid anabolism, including the
      adipocyte fatty acid binding protein (aP2), and is a key regulator of adipocyte
      differentiation. PPARgamma is also expressed in hematopoietic cells and is
      up-regulated in activated monocytes/macrophages. Activation of PPARgamma may play
      a role in the induction of differentiation of macrophages to foam cells that are 
      associated with atherosclerotic lesions. We report that both natural and
      synthetic PPARgamma agonists induce time- and dose-dependent increases in aP2
      mRNA in both primary human monocytes and the monocytic cell line, THP-1. These
      data suggest that PPARgamma activation may play a role in monocyte
      differentiation and function analogous to its well-characterized role in
      adipocytes.
CI  - Copyright 1999 Academic Press.
FAU - Pelton, P D
AU  - Pelton PD
AD  - Endocrine Therapeutics, R. W. Johnson Pharmaceutical Research Institute, Raritan,
      New Jersey, 08869, USA.
FAU - Zhou, L
AU  - Zhou L
FAU - Demarest, K T
AU  - Demarest KT
FAU - Burris, T P
AU  - Burris TP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (15-deoxy-delta(12,14)-prostaglandin J2)
RN  - 0 (Carrier Proteins)
RN  - 0 (Chromans)
RN  - 0 (FABP7 protein, human)
RN  - 0 (Fatty Acid-Binding Protein 7)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Fatty Acids)
RN  - 0 (Myelin P2 Protein)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Thiazoles)
RN  - 0 (Thiazolidinediones)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 05V02F2KDG (Rosiglitazone)
RN  - I66ZZ0ZN0E (Troglitazone)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
RN  - RXY07S6CZ2 (Prostaglandin D2)
SB  - IM
MH  - Adipocytes/*metabolism
MH  - Carrier Proteins/*genetics
MH  - Cell Differentiation/drug effects
MH  - Cell Line
MH  - Cells, Cultured
MH  - Chromans/pharmacology
MH  - Fatty Acid-Binding Protein 7
MH  - Fatty Acid-Binding Proteins
MH  - Fatty Acids/*metabolism
MH  - Gene Expression/drug effects
MH  - Humans
MH  - Kinetics
MH  - Monocytes/cytology/drug effects/*metabolism
MH  - Myelin P2 Protein/*genetics
MH  - *Neoplasm Proteins
MH  - Prostaglandin D2/analogs & derivatives/pharmacology
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptors, Cytoplasmic and Nuclear/agonists/*metabolism
MH  - Rosiglitazone
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - Thiazoles/pharmacology
MH  - *Thiazolidinediones
MH  - Transcription Factors/agonists/*metabolism
MH  - Troglitazone
MH  - *Tumor Suppressor Proteins
EDAT- 1999/07/30 00:00
MHDA- 1999/07/30 00:01
CRDT- 1999/07/30 00:00
PHST- 1999/07/30 00:00 [pubmed]
PHST- 1999/07/30 00:01 [medline]
PHST- 1999/07/30 00:00 [entrez]
AID - 10.1006/bbrc.1999.1071 [doi]
AID - S0006-291X(99)91071-9 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Aug 2;261(2):456-8. doi: 10.1006/bbrc.1999.1071.