PMID- 10424734
OWN - NLM
STAT- MEDLINE
DCOM- 19990805
LR  - 20181113
IS  - 0007-0920 (Print)
IS  - 0007-0920 (Linking)
VI  - 80
IP  - 9
DP  - 1999 Jul
TI  - MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney
      and liver.
PG  - 1342-9
AB  - Multidrug resistance-associated protein (MRP) and the canalicular multispecific
      organic anion transporter (cMOAT) are organic anion pumps that have been linked
      to cytotoxic drug resistance. We previously reported the isolation of three human
      MRP/cMOAT-related transporters, MOAT-B (MRP4), MOAT-C (MRP5) and MOAT-D (MRP3).
      In the present study we describe the fourth MRP/cMOAT-related transporter. We
      analysed ARA, a human cDNA reported to encode a 453 residue MRP-related
      transporter, and found that it represents a fused transcript composed of MRP
      sequences and partial sequences of a novel transporter. The complete coding
      sequence of this novel transporter, which we designated MOAT-E, was isolated.
      MOAT-E encodes a 1503 residue transporter that is most closely related to MRP
      (45%), MOAT-D (44%) and cMOAT (39%), both in terms of amino acid identity and
      sharing a common topology in which approximately 17 transmembrane spanning
      helices are distributed within three membrane spanning domains. RNA blot analysis
      indicated that MOAT-E expression is restricted to kidney and liver. These
      observations suggest that MOAT-E may function as an organic anion transporter
      involved in cellular detoxification and possibly in the hepatobiliary and renal
      excretion of xenobiotics and/or endogenous metabolites. Isolation of MOAT-E helps
      to define the MRP/cMOAT subfamily of transporters.
FAU - Belinsky, M G
AU  - Belinsky MG
AD  - Division of Medical Sciences, Fox Chase Cancer Center, Philadelphia, PA 19111,
      USA.
FAU - Kruh, G D
AU  - Kruh GD
LA  - eng
GR  - CA06927/CA/NCI NIH HHS/United States
GR  - CA63173/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Anion Transport Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Multidrug Resistance-Associated Proteins)
SB  - IM
MH  - ATP-Binding Cassette Transporters/*analysis/chemistry/genetics
MH  - Amino Acid Sequence
MH  - Anion Transport Proteins
MH  - Carrier Proteins/*analysis/chemistry/genetics
MH  - DNA, Complementary/isolation & purification
MH  - Humans
MH  - Kidney/*chemistry
MH  - Liver/*chemistry
MH  - Molecular Sequence Data
MH  - Multidrug Resistance-Associated Proteins
PMC - PMC2363063
EDAT- 1999/07/29 00:00
MHDA- 1999/07/29 00:01
CRDT- 1999/07/29 00:00
PHST- 1999/07/29 00:00 [pubmed]
PHST- 1999/07/29 00:01 [medline]
PHST- 1999/07/29 00:00 [entrez]
AID - 10.1038/sj.bjc.6690527 [doi]
PST - ppublish
SO  - Br J Cancer. 1999 Jul;80(9):1342-9. doi: 10.1038/sj.bjc.6690527.