PMID- 10422847
OWN - NLM
STAT- MEDLINE
DCOM- 19990913
LR  - 20181113
IS  - 0961-8368 (Print)
IS  - 0961-8368 (Linking)
VI  - 8
IP  - 7
DP  - 1999 Jul
TI  - TRIADs: a new class of proteins with a novel cysteine-rich signature.
PG  - 1557-61
AB  - Triad1 was recently identified as a nuclear RING finger protein, which is
      up-regulated during retinoic acid induced granulocytic differentiation of acute
      leukemia cells. Here we show that a cysteine-rich domain (C6HC), present in
      Triad1, is conserved in at least 24 proteins encoded by various eukaryotes. The
      C6HC consensus pattern C-x(4)-C-x(14-30)-C-x(1-4)-C-x(4)-C-x(2)-C-x(4)-H-x(4)-C
      defines this structure as the fourth family member of the zinc-binding RING, LIM,
      and LAP/PHD fingers. Strikingly, in 22 of 24 proteins the C6HC domain is flanked 
      by two RING finger structures. We have termed the novel C6HC motif DRIL (double
      RING finger linked). The strong conservation of the larger tripartite TRIAD (two 
      RING fingers and DRIL) structure indicates that the three subdomains are
      functionally linked and identifies a novel class of proteins.
FAU - van der Reijden, B A
AU  - van der Reijden BA
AD  - Institute of Hematology, Erasmus University Rotterdam, The Netherlands.
      vanderreijden@hema.fgg.eur.nl
FAU - Erpelinck-Verschueren, C A
AU  - Erpelinck-Verschueren CA
FAU - Lowenberg, B
AU  - Lowenberg B
FAU - Jansen, J H
AU  - Jansen JH
LA  - eng
SI  - GENBANK/AF099149
SI  - GENBANK/AF099150
SI  - GENBANK/AF099151
SI  - GENBANK/AF099152
SI  - GENBANK/AF099153
SI  - GENBANK/AF228527
SI  - GENBANK/AF249667
SI  - GENBANK/AF249668
PT  - Journal Article
PL  - United States
TA  - Protein Sci
JT  - Protein science : a publication of the Protein Society
JID - 9211750
RN  - 0 (Carrier Proteins)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/*chemistry
MH  - Conserved Sequence
MH  - Cysteine/*chemistry
MH  - Humans
MH  - Molecular Sequence Data
MH  - Sequence Homology, Amino Acid
MH  - Zinc Fingers
PMC - PMC2144383
EDAT- 1999/07/28 00:00
MHDA- 1999/07/28 00:01
CRDT- 1999/07/28 00:00
PHST- 1999/07/28 00:00 [pubmed]
PHST- 1999/07/28 00:01 [medline]
PHST- 1999/07/28 00:00 [entrez]
AID - 10.1110/ps.8.7.1557 [doi]
PST - ppublish
SO  - Protein Sci. 1999 Jul;8(7):1557-61. doi: 10.1110/ps.8.7.1557.