PMID- 10421837
OWN - NLM
STAT- MEDLINE
DCOM- 19990818
LR  - 20191103
IS  - 1356-9597 (Print)
IS  - 1356-9597 (Linking)
VI  - 4
IP  - 5
DP  - 1999 May
TI  - Expression of the Vax family homeobox genes suggests multiple roles in eye
      development.
PG  - 267-76
AB  - BACKGROUND: Homeobox gene products are thought to regulate target genes involved 
      in the regional specification of tissues and organs. Several genes play roles in 
      eye development. RESULTS: We isolated two new mouse homeobox genes, Vax1 and
      Vax2, expressed in retina primordium. The two genes share the same gene
      organization, consisting of three exons with predicted amino acid sequences
      identical in the homeodomain but diversified in other regions. At 9. 5 days post 
      coitum, both Vax genes were expressed in optic vesicles. At 11.5-14.5 dpc, Vax1
      became restricted to the optic stalk, while Vax2 was expressed in the ventral
      half of the neural retina. Mapping of Vax2 between D6Mit3 and D6Mit8 on
      chromosome 6 indicated a possible linkage with Emx1. CONCLUSIONS: The expression 
      patterns of Vax genes suggest separate and specific involvement in eye
      development. Vax1 may contribute to differentiation of the neuroretina, pigmented
      epithelium and optic stalk, while Vax2 could function in the establishment of the
      dorso-ventral axis of the retina and the visual system. The chromosomal location 
      of Vax2 suggests that Vax2-Emx1 and Vax1-Emx2 arose by chromosome duplication of 
      the same ancestral gene.
FAU - Ohsaki, K
AU  - Ohsaki K
AD  - Graduate School of Biological Sciences, Nara Institute of Science and Technology,
      8916-5, Takayama, Ikoma, Nara, 630-0101, Japan.
FAU - Morimitsu, T
AU  - Morimitsu T
FAU - Ishida, Y
AU  - Ishida Y
FAU - Kominami, R
AU  - Kominami R
FAU - Takahashi, N
AU  - Takahashi N
LA  - eng
SI  - GENBANK/AB020493
SI  - GENBANK/AB020494
SI  - GENBANK/AB020495
SI  - GENBANK/AB020496
SI  - GENBANK/AB020497
SI  - GENBANK/AB020498
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Genes Cells
JT  - Genes to cells : devoted to molecular & cellular mechanisms
JID - 9607379
RN  - 0 (DNA, Complementary)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (VAX2 protein, human)
RN  - 0 (Vax1 protein, mouse)
RN  - 0 (Vax2 protein, mouse)
RN  - 0 (Xenopus Proteins)
RN  - 0 (vax2 protein, Xenopus)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - DNA/chemistry/genetics
MH  - DNA, Complementary/chemistry/genetics/isolation & purification
MH  - Embryo, Mammalian/metabolism
MH  - Embryonic and Fetal Development
MH  - Eye/embryology/*metabolism
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Homeobox/*genetics/physiology
MH  - Homeodomain Proteins/*genetics
MH  - Humans
MH  - In Situ Hybridization
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred ICR
MH  - Molecular Sequence Data
MH  - Neuropeptides/*genetics
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - *Xenopus Proteins
EDAT- 1999/07/28 00:00
MHDA- 1999/07/28 00:01
CRDT- 1999/07/28 00:00
PHST- 1999/07/28 00:00 [pubmed]
PHST- 1999/07/28 00:01 [medline]
PHST- 1999/07/28 00:00 [entrez]
AID - gtc257 [pii]
AID - 10.1046/j.1365-2443.1999.00257.x [doi]
PST - ppublish
SO  - Genes Cells. 1999 May;4(5):267-76. doi: 10.1046/j.1365-2443.1999.00257.x.