PMID- 10421793
OWN - NLM
STAT- MEDLINE
DCOM- 19990924
LR  - 20190513
IS  - 0953-8178 (Print)
IS  - 0953-8178 (Linking)
VI  - 11
IP  - 8
DP  - 1999 Aug
TI  - IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB
      kinases.
PG  - 1357-62
AB  - Using the suppression subtractive hybridization technique, we isolated a novel
      kinase, IKK-i, whose message is drastically induced by lipopolysaccharide (LPS)
      in the mouse macrophage cell line RAW264. 7. The predicted protein contains the
      kinase domain in its N-terminus, which shares 30% identity to that of IKK-alpha
      or IKK-beta. The C-terminal portion contains a leucine zipper and a potential
      helix-loop-helix domain, as in the case of IKK-alpha and IKK-beta. IKK-i is
      expressed mainly in immune cells, and is induced in response to proinflammatory
      cytokines such as tumor necrosis factor-alpha, IL-1 and IL-6, in addition to LPS.
      Overexpression of wild-type IKK-i phosphorylated serine residues Ser32 and Ser36 
      of IkappaB-alpha (preferentially Ser36), and significantly stimulated NF-kappaB
      activation. These results suggest that IKK-i is an inducible IkappaB kinase which
      may play a special role in the immune response.
FAU - Shimada, T
AU  - Shimada T
AD  - Department of Biochemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho,
      Nishinomiya, Hyogo 663-8501, Japan.
FAU - Kawai, T
AU  - Kawai T
FAU - Takeda, K
AU  - Takeda K
FAU - Matsumoto, M
AU  - Matsumoto M
FAU - Inoue, J
AU  - Inoue J
FAU - Tatsumi, Y
AU  - Tatsumi Y
FAU - Kanamaru, A
AU  - Kanamaru A
FAU - Akira, S
AU  - Akira S
LA  - eng
SI  - GENBANK/AB016589
SI  - GENBANK/AB016590
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Cytokines)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (I-kappa B Proteins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (NFKBIA protein, human)
RN  - 0 (Nfkbia protein, mouse)
RN  - 139874-52-5 (NF-KappaB Inhibitor alpha)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.10 (CHUK protein, human)
RN  - EC 2.7.11.10 (Chuk protein, mouse)
RN  - EC 2.7.11.10 (I-kappa B Kinase)
RN  - EC 2.7.11.10 (IKBKB protein, human)
RN  - EC 2.7.11.10 (IKBKE protein, human)
RN  - EC 2.7.11.10 (Ikbkb protein, mouse)
RN  - EC 2.7.11.10 (Ikbke protein, mouse)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cytokines/immunology
MH  - DNA-Binding Proteins/metabolism
MH  - Enzyme Induction
MH  - Humans
MH  - I-kappa B Kinase
MH  - *I-kappa B Proteins
MH  - Inflammation/immunology
MH  - Lipopolysaccharides/*pharmacology
MH  - Macrophage Activation
MH  - Macrophages/*enzymology/*immunology
MH  - Mice
MH  - Molecular Sequence Data
MH  - NF-KappaB Inhibitor alpha
MH  - NF-kappa B/metabolism
MH  - Phosphorylation
MH  - Protein-Serine-Threonine Kinases/chemistry/genetics/*metabolism
MH  - Sequence Analysis, DNA
MH  - Transcriptional Activation
EDAT- 1999/07/28 00:00
MHDA- 1999/07/28 00:01
CRDT- 1999/07/28 00:00
PHST- 1999/07/28 00:00 [pubmed]
PHST- 1999/07/28 00:01 [medline]
PHST- 1999/07/28 00:00 [entrez]
AID - 10.1093/intimm/11.8.1357 [doi]
PST - ppublish
SO  - Int Immunol. 1999 Aug;11(8):1357-62. doi: 10.1093/intimm/11.8.1357.