PMID- 10419693
OWN - NLM
STAT- MEDLINE
DCOM- 19990824
LR  - 20071115
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 212
IP  - 1
DP  - 1999 Aug 1
TI  - Neurestin: putative transmembrane molecule implicated in neuronal development.
PG  - 165-81
AB  - We have cloned a novel cDNA encoding a putative transmembrane protein, neurestin,
      from the rat olfactory bulb. Neurestin was identified based on a sequence similar
      to that of the second extracellular loops of odorant receptors in the
      cysteine-rich CC box located immediately after EGF-like motifs. Neurestin shows
      homology to a neuregulin gene product, human gamma-heregulin, a Drosophila
      receptor-type pair-rule gene product, Odd Oz (Odz) / Ten(m), and Ten(a),
      suggesting a possible function in synapse formation and morphogenesis. Recently, 
      a mouse neurestin homolog has independently been cloned as DOC4 from the NIH-3T3 
      cell line. Northern blot analysis showed that neurestin is highly expressed in
      the brain and also in other tissues at much lower levels. In situ hybridization
      studies showed that neurestin is expressed in many types of neurons, including
      pyramidal cells in the cerebral cortex and tufted cells in the olfactory bulb
      during development. In adults, neurestin is mainly expressed in olfactory and
      hippocampal granule cells, which are known to be generated throughout adulthood. 
      Nonetheless, in adults the expression of neurestin was experimentally induced in 
      external tufted cells during regeneration of olfactory sensory neurons. These
      results suggest a role for neurestin in neuronal development and regeneration in 
      the central nervous system.
CI  - Copyright 1999 Academic Press.
FAU - Otaki, J M
AU  - Otaki JM
AD  - Department of Biological Sciences, Columbia University, New York, New York,
      10027, USA. jm302@columbia.edu
FAU - Firestein, S
AU  - Firestein S
LA  - eng
SI  - GENBANK/AF086607
SI  - GENBANK/AF086608
SI  - GENBANK/AF086609
SI  - GENBANK/AF086610
GR  - DC00920-09/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (DNA, Complementary)
RN  - 0 (Membrane Proteins)
RN  - 0 (neurestin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cerebral Cortex/anatomy & histology
MH  - Cloning, Molecular
MH  - DNA, Complementary/analysis
MH  - Embryo, Mammalian/anatomy & histology
MH  - Gene Expression
MH  - Gene Library
MH  - Humans
MH  - Immunohistochemistry
MH  - Membrane Proteins/analysis/*chemistry/*pharmacology
MH  - Models, Biological
MH  - Molecular Sequence Data
MH  - Olfactory Bulb/anatomy & histology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sequence Homology, Amino Acid
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 1999/07/27 00:00
MHDA- 1999/07/27 00:01
CRDT- 1999/07/27 00:00
PHST- 1999/07/27 00:00 [pubmed]
PHST- 1999/07/27 00:01 [medline]
PHST- 1999/07/27 00:00 [entrez]
AID - 10.1006/dbio.1999.9310 [doi]
AID - S0012-1606(99)99310-7 [pii]
PST - ppublish
SO  - Dev Biol. 1999 Aug 1;212(1):165-81. doi: 10.1006/dbio.1999.9310.