PMID- 10419686
OWN - NLM
STAT- MEDLINE
DCOM- 19990824
LR  - 20081124
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 212
IP  - 1
DP  - 1999 Aug 1
TI  - Characterization of GDF-10 expression patterns and null mice.
PG  - 68-79
AB  - Growth/differentiation factor-10 (GDF-10) is a TGF-beta family member highly
      related to bone morphogenetic protein-3. In order to determine the biological
      function of GDF-10, we carried out a detailed analysis of the expression pattern 
      of GDF-10 and characterized GDF-10-null mice that we generated by gene targeting.
      During embryogenesis GDF-10 is expressed prominently in developing skeletal
      structures both in the craniofacial region and in the vertebral column. In adult 
      animals, GDF-10 is expressed at high levels in the brain, where GDF-10 is
      localized primarily to cells in the Purkinje cell layer of the cerebellum, and in
      the uterus, where the expression levels of GDF-10 are regulated both during the
      menstrual cycle and during pregnancy. Despite the high levels of GDF-10
      expression in these tissues, we found no obvious abnormalities in GDF-10-knockout
      mice with respect to the development of these tissues. These findings suggest
      either that GDF-10 plays no regulatory role in these tissues or that its function
      is redundant with that of other growth factor-like molecules.
CI  - Copyright 1999 Academic Press.
FAU - Zhao, R
AU  - Zhao R
AD  - Department of Molecular Biology and Genetics, Department of Gynecology and
      Obstetrics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, 
      Baltimore, Maryland, 21205, USA.
FAU - Lawler, A M
AU  - Lawler AM
FAU - Lee, S J
AU  - Lee SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Bone Morphogenetic Protein 3)
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Gdf10 protein, mouse)
RN  - 0 (Growth Differentiation Factor 10)
RN  - 0 (Growth Substances)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Bone Morphogenetic Protein 3
MH  - Bone Morphogenetic Proteins/metabolism
MH  - Brain/anatomy & histology/embryology/metabolism
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - Genotype
MH  - Growth Differentiation Factor 10
MH  - Growth Substances/*genetics/metabolism/physiology
MH  - Immunohistochemistry
MH  - Menstrual Cycle/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Models, Genetic
MH  - Placenta/anatomy & histology/metabolism
MH  - Pregnancy
MH  - Pregnancy, Animal
MH  - Time Factors
MH  - Tissue Distribution
MH  - Uterus/anatomy & histology/embryology
EDAT- 1999/07/27 00:00
MHDA- 1999/07/27 00:01
CRDT- 1999/07/27 00:00
PHST- 1999/07/27 00:00 [pubmed]
PHST- 1999/07/27 00:01 [medline]
PHST- 1999/07/27 00:00 [entrez]
AID - 10.1006/dbio.1999.9326 [doi]
AID - S0012-1606(99)99326-0 [pii]
PST - ppublish
SO  - Dev Biol. 1999 Aug 1;212(1):68-79. doi: 10.1006/dbio.1999.9326.