PMID- 10419538
OWN - NLM
STAT- MEDLINE
DCOM- 19990819
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 31
DP  - 1999 Jul 30
TI  - Cloning and characterization of human polyamine-modulated factor-1, a
      transcriptional cofactor that regulates the transcription of the
      spermidine/spermine N(1)-acetyltransferase gene.
PG  - 22095-101
AB  - The increased transcription and ultimate superinduction of the
      spermidine/spermine N(1)-acetyltransferase (SSAT) gene has been associated with
      the antineoplastic activity of several new antitumor polyamine analogues. In
      sensitive tumor cell types, the transcriptional induction appears to be regulated
      by the constitutive association of the transcription factor Nrf-2 with the
      recently discovered polyamine-responsive element. Using the yeast two-hybrid
      system, a new transcriptional cofactor, polyamine-modulated factor-1 (PMF-1), has
      been identified as a partner protein of Nrf-2 that, in combination with Nrf-2,
      regulates the polyamine analogue-induced transcription of SSAT. The human PMF-1
      gene, located on chromosome 1 near the 1q12/1q21 border, yields an mRNA
      transcript of approximately 1.2 kilobases that codes for a 165-amino acid protein
      with a predicted molecular mass of approximately 20 kDa. The PMF-1 mRNA appears
      to increase in response to analogue exposure only in analogue-responsive cells.
      In addition to the transcriptional regulation of SSAT, PMF-1 or similar factors
      should be considered in the regulation of other polyamine-dependent genes.
FAU - Wang, Y
AU  - Wang Y
AD  - Johns Hopkins Oncology Center Research Laboratories, Baltimore, Maryland 21231,
      USA.
FAU - Devereux, W
AU  - Devereux W
FAU - Stewart, T M
AU  - Stewart TM
FAU - Casero, R A Jr
AU  - Casero RA Jr
LA  - eng
SI  - GENBANK/AF141308
SI  - GENBANK/AF141309
SI  - GENBANK/AF141310
SI  - GENBANK/AH008078
GR  - CA51085/CA/NCI NIH HHS/United States
GR  - CA58184/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA Primers)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
RN  - 0 (PMF1 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.- (Acetyltransferases)
RN  - EC 2.3.1.57 (diamine N-acetyltransferase)
SB  - IM
MH  - Acetyltransferases/*genetics
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cell Line
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 1
MH  - Cloning, Molecular
MH  - DNA Primers
MH  - DNA-Binding Proteins/metabolism
MH  - Exons
MH  - Female
MH  - *Gene Expression Regulation, Enzymologic
MH  - Gene Library
MH  - Humans
MH  - Introns
MH  - Molecular Sequence Data
MH  - Molecular Weight
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Placenta/metabolism
MH  - Pregnancy
MH  - RNA, Messenger/genetics
MH  - Recombinant Proteins/chemistry
MH  - Transcription Factors/chemistry/*genetics/*metabolism
MH  - *Transcription, Genetic
MH  - Transfection
EDAT- 1999/07/27 10:00
MHDA- 2001/03/28 10:01
CRDT- 1999/07/27 10:00
PHST- 1999/07/27 10:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1999/07/27 10:00 [entrez]
AID - 10.1074/jbc.274.31.22095 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Jul 30;274(31):22095-101. doi: 10.1074/jbc.274.31.22095.