PMID- 10417823
OWN - NLM
STAT- MEDLINE
DCOM- 19991027
LR  - 20091119
IS  - 1058-8388 (Print)
IS  - 1058-8388 (Linking)
VI  - 215
IP  - 4
DP  - 1999 Aug
TI  - Expression of Melk, a new protein kinase, during early mouse development.
PG  - 344-51
AB  - A new gene named maternal embryonic leucine zipper kinase, Melk, has been
      recently identified (Heyer et al. [1997] Mol. Reprod. Dev. 47:148-156). As a
      basis for further study of the function of the gene, we have examined the
      expression of Melk across a wide range of embryonic stages, from the ovulated egg
      and 2-cell embryo through the gastrulation and early organogenesis stages, by in 
      situ hybridization and immunohistochemistry. Melk is expressed in a spatially and
      temporally specific pattern during mammalian embryogenesis. The strongest
      expression was detected during maturation of oocytes and preimplantation
      development. Given its expression pattern, Melk may play an important role during
      preimplantation embryonic development. Dev Dyn 1999;215:344-351.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Heyer, B S
AU  - Heyer BS
AD  - Max-Planck-Institut fur Immunbiologie, Freiburg, Germany.
FAU - Kochanowski, H
AU  - Kochanowski H
FAU - Solter, D
AU  - Solter D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Dyn
JT  - Developmental dynamics : an official publication of the American Association of
      Anatomists
JID - 9201927
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (Melk protein, mouse)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Conserved Sequence
MH  - Embryonic Development/physiology
MH  - Embryonic and Fetal Development
MH  - Female
MH  - Gastrula/metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Germ Cells/metabolism
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Mice/anatomy & histology/*embryology
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Pregnancy
MH  - Protein Kinases/metabolism
MH  - Protein-Serine-Threonine Kinases/analysis/*genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 1999/07/27 00:00
MHDA- 1999/07/27 00:01
CRDT- 1999/07/27 00:00
PHST- 1999/07/27 00:00 [pubmed]
PHST- 1999/07/27 00:01 [medline]
PHST- 1999/07/27 00:00 [entrez]
AID - 10.1002/(SICI)1097-0177(199908)215:4<344::AID-AJA6>3.0.CO;2-H [pii]
AID - 10.1002/(SICI)1097-0177(199908)215:4<344::AID-AJA6>3.0.CO;2-H [doi]
PST - ppublish
SO  - Dev Dyn. 1999 Aug;215(4):344-51. doi:
      10.1002/(SICI)1097-0177(199908)215:4<344::AID-AJA6>3.0.CO;2-H.