PMID- 10417819
OWN - NLM
STAT- MEDLINE
DCOM- 19991027
LR  - 20071114
IS  - 1058-8388 (Print)
IS  - 1058-8388 (Linking)
VI  - 215
IP  - 4
DP  - 1999 Aug
TI  - Differential developmentally regulated expression of gelsolin family members in
      the mouse.
PG  - 297-307
AB  - The gelsolin family of actin-modulating proteins contains seven mammalian members
      of which three have similar domain structure and function: gelsolin, capG, and
      adseverin. Previous studies have provided some information on the expression of
      these proteins, but no comprehensive analysis of expression during development
      has been performed. By in situ hybridization to murine embryo sections, we show
      that gelsolin expression is widespread but focal from e12.5 onward, with the
      exception of brain and mucosal epithelium. In contrast, CapG expression is high
      in mucosal epithelium, inner renal medulla, and adrenal cortex, and seen at much 
      lower levels more broadly. Adseverin expression is even more restricted, being
      seen at sites of endochondral bone formation during development only, and in
      developing and adult outer renal medulla and intestine. In parallel analyses the 
      three genes demonstrated patterns of expression that were complementary and
      non-overlapping in nearly all organs. The observations suggest new functions for 
      these proteins in organ systems and tissues where their expression was not
      previously recognized. They further suggest that the proteins have distinct
      tissue-specific functions in modulating the actin cytoskeleton during cellular
      motile activities, and that such functions have diverged since the genes arose
      ancestrally by gene duplication. Dev Dyn 1999;215:297-307.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Arai, M
AU  - Arai M
AD  - Genetics Laboratory, Hematology Division, Brigham and Women's Hospital, Harvard
      Medical School, Boston, Massachusetts, USA.
FAU - Kwiatkowski, D J
AU  - Kwiatkowski DJ
LA  - eng
GR  - HL48743/HL/NHLBI NIH HHS/United States
GR  - HL54188/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Dyn
JT  - Developmental dynamics : an official publication of the American Association of
      Anatomists
JID - 9201927
RN  - 0 (Gelsolin)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (scinderin)
RN  - 136896-19-0 (Capg protein, mouse)
SB  - IM
MH  - Adrenal Glands/anatomy & histology/embryology
MH  - Animals
MH  - Cytoplasm/metabolism
MH  - Female
MH  - Gelsolin/analysis/blood/*metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Immunohistochemistry
MH  - Kidney/anatomy & histology/embryology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Microfilament Proteins/analysis/*metabolism
MH  - Nuclear Proteins/analysis/*metabolism
MH  - Time Factors
MH  - Tissue Distribution
MH  - Tongue/anatomy & histology/embryology
EDAT- 1999/07/27 00:00
MHDA- 1999/07/27 00:01
CRDT- 1999/07/27 00:00
PHST- 1999/07/27 00:00 [pubmed]
PHST- 1999/07/27 00:01 [medline]
PHST- 1999/07/27 00:00 [entrez]
AID - 10.1002/(SICI)1097-0177(199908)215:4<297::AID-AJA2>3.0.CO;2-I [pii]
AID - 10.1002/(SICI)1097-0177(199908)215:4<297::AID-AJA2>3.0.CO;2-I [doi]
PST - ppublish
SO  - Dev Dyn. 1999 Aug;215(4):297-307. doi:
      10.1002/(SICI)1097-0177(199908)215:4<297::AID-AJA2>3.0.CO;2-I.