PMID- 10417285
OWN - NLM
STAT- MEDLINE
DCOM- 19990820
LR  - 20181113
IS  - 0002-9297 (Print)
IS  - 0002-9297 (Linking)
VI  - 65
IP  - 2
DP  - 1999 Aug
TI  - A gene for lymphedema-distichiasis maps to 16q24.3.
PG  - 427-32
AB  - Lymphedema-distichiasis (LD) is a dominantly inherited syndrome with onset of
      lymphedema at or just after puberty. Most affected individuals have
      distichiasis-fine hairs arising inappropriately from the eyelid meibomian
      glands-which is evident from birth. A study of three families with LD has shown
      linkage to chromosome 16q24.3, and subsequent analysis of the region for
      recombinant genes places the locus between D16S422 and D16S3074, a distance of
      approximately 16 cM. Possible candidate genes in this interval include the
      N-proteinase for type 3 collagen, PCOLN3; the metalloprotease PRSM1; and the cell
      matrix-adhesion regulator, CMAR.
FAU - Mangion, J
AU  - Mangion J
AD  - Institute of Cancer Research, United Medical and Dental School, St. Thomas'
      Hospital, London, UK.
FAU - Rahman, N
AU  - Rahman N
FAU - Mansour, S
AU  - Mansour S
FAU - Brice, G
AU  - Brice G
FAU - Rosbotham, J
AU  - Rosbotham J
FAU - Child, A H
AU  - Child AH
FAU - Murday, V A
AU  - Murday VA
FAU - Mortimer, P S
AU  - Mortimer PS
FAU - Barfoot, R
AU  - Barfoot R
FAU - Sigurdsson, A
AU  - Sigurdsson A
FAU - Edkins, S
AU  - Edkins S
FAU - Sarfarazi, M
AU  - Sarfarazi M
FAU - Burnand, K
AU  - Burnand K
FAU - Evans, A L
AU  - Evans AL
FAU - Nunan, T O
AU  - Nunan TO
FAU - Stratton, M R
AU  - Stratton MR
FAU - Jeffery, S
AU  - Jeffery S
LA  - eng
SI  - OMIM/153200
SI  - OMIM/153400
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Chromosomes, Human, Pair 16/*genetics
MH  - Female
MH  - Genetic Linkage/genetics
MH  - Genetic Markers/genetics
MH  - Humans
MH  - Lymphedema/diagnosis/*genetics
MH  - Male
MH  - Molecular Sequence Data
MH  - Pedigree
MH  - *Physical Chromosome Mapping
PMC - PMC1377941
EDAT- 1999/07/27 10:00
MHDA- 2000/03/21 09:00
CRDT- 1999/07/27 10:00
PHST- 1999/07/27 10:00 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/07/27 10:00 [entrez]
AID - S0002-9297(07)62059-X [pii]
AID - 10.1086/302500 [doi]
PST - ppublish
SO  - Am J Hum Genet. 1999 Aug;65(2):427-32. doi: 10.1086/302500.