PMID- 10415854
OWN - NLM
STAT- MEDLINE
DCOM- 19990819
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 880
DP  - 1999 Jun 30
TI  - Sp1 and its likes: biochemical and functional predictions for a growing family of
      zinc finger transcription factors.
PG  - 94-102
AB  - The discovery and functional characterization of Sp1 as a GC-rich binding zinc
      finger protein provided a useful paradigm for understanding mechanisms mediating 
      transcriptional activation in eukaryotic cells. This early paradigm suggested
      that promoters carrying GC-rich sequences are activated by Sp1 through its
      interaction with proteins from the basal transcriptional machinery to upregulate 
      gene expression. Since the time of this seminal work, studies from several
      laboratories have led to the discovery of many Sp1-like transcription factors
      containing highly homologous DNA binding motifs that bind to similar sequences.
      Consequently, this knowledge poses many important questions regarding whether
      these related proteins have similar or antagonistic biochemical and functional
      properties to Sp1. The goal of this article is to use available database
      information and recent experimental evidence to describe the current repertoire
      of Sp1-like zinc finger transcription factors in mammalian cells. Furthermore, we
      discuss structural and functional studies that reveal that these proteins may
      share a role in morphogenetic pathways. Altogether, this information is aimed at 
      better understanding how this growing family of transcription factors work to
      regulate gene expression and morphogenesis.
FAU - Cook, T
AU  - Cook T
AD  - Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.
FAU - Gebelein, B
AU  - Gebelein B
FAU - Urrutia, R
AU  - Urrutia R
LA  - eng
GR  - R01 DK052913/DK/NIDDK NIH HHS/United States
GR  - R01 DK052913-03/DK/NIDDK NIH HHS/United States
GR  - DK52913/DK/NIDDK NIH HHS/United States
GR  - DK07198/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Sp1 Transcription Factor)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Humans
MH  - Molecular Sequence Data
MH  - Sp1 Transcription Factor/chemistry/metabolism/*physiology
MH  - Transcription Factors/chemistry/metabolism/*physiology
MH  - *Zinc Fingers
RF  - 38
EDAT- 1999/07/23 00:00
MHDA- 1999/07/23 00:01
CRDT- 1999/07/23 00:00
PHST- 1999/07/23 00:00 [pubmed]
PHST- 1999/07/23 00:01 [medline]
PHST- 1999/07/23 00:00 [entrez]
AID - 10.1111/j.1749-6632.1999.tb09513.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1999 Jun 30;880:94-102. doi:
      10.1111/j.1749-6632.1999.tb09513.x.