PMID- 10415718
OWN - NLM
STAT- MEDLINE
DCOM- 19990811
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 878
DP  - 1999 Jun 30
TI  - Evaluation of some newer matrix metalloproteinases.
PG  - 25-39
AB  - Recombinant protein expression techniques have been utilized to facilitate the
      biochemical and cell biological characterization of human matrix
      metalloproteinases (MMPs). The importance of the membrane type 1 MMP (MMP 14) in 
      the regulation of pericellular proteolysis, either directly or through the
      activation of MMP-2, MMP-9, and MMP-13 has been identified. Studies on an in
      vitro chondrocyte-like cell and an in vivo cartilage repair model indicated that 
      such MT1 MMP-regulated activation cascades are physiologically feasible. MMP19
      shows a limited sequence identity with other MMPs and may represent a novel
      subclass. However, analysis of the recombinant protein identified a number of
      biochemical properties typical of the MMP family.
FAU - Murphy, G
AU  - Murphy G
AD  - School of Biological Sciences, University of East Anglia, Norwich, UK.
      g.murphy@uea.ac.uk
FAU - Knauper, V
AU  - Knauper V
FAU - Cowell, S
AU  - Cowell S
FAU - Hembry, R
AU  - Hembry R
FAU - Stanton, H
AU  - Stanton H
FAU - Butler, G
AU  - Butler G
FAU - Freije, J
AU  - Freije J
FAU - Pendas, A M
AU  - Pendas AM
FAU - Lopez-Otin, C
AU  - Lopez-Otin C
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases, Secreted)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.- (matrix metalloproteinase 19)
SB  - IM
MH  - Animals
MH  - Enzyme Activation
MH  - Extracellular Matrix/*physiology
MH  - Humans
MH  - Matrix Metalloproteinases, Secreted
MH  - Metalloendopeptidases/genetics/*metabolism
MH  - Models, Biological
MH  - Recombinant Proteins/metabolism
MH  - Tissue Inhibitor of Metalloproteinases/pharmacology/*physiology
RF  - 29
EDAT- 1999/07/23 00:00
MHDA- 1999/07/23 00:01
CRDT- 1999/07/23 00:00
PHST- 1999/07/23 00:00 [pubmed]
PHST- 1999/07/23 00:01 [medline]
PHST- 1999/07/23 00:00 [entrez]
AID - 10.1111/j.1749-6632.1999.tb07672.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1999 Jun 30;878:25-39. doi: 10.1111/j.1749-6632.1999.tb07672.x.