PMID- 10415337
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 235
IP  - 1-2
DP  - 1999 Jul 22
TI  - Identification of a novel gene encoding a p53-associated protein.
PG  - 93-101
AB  - p53 exerts important physiological functions in cell-cycle control, gene
      regulation, cell differentiation, apoptosis and tumor suppression by interacting 
      with many cellular proteins. Using the yeast two-hybrid system, we screened a
      HeLa cDNA library and identified a novel gene encoding a p53-binding protein
      (p53BP3). The full-length cDNA of p53BP3 was isolated from a HeLalambdagt10 cDNA 
      library. This predicted protein was composed of 815 amino acids. Sequence
      analysis indicated that p53BP3 contained two bipartite nuclear localization
      signals and was confirmed to be a nuclear protein. FISH mapping results showed
      that this novel gene was located at human chromosome 12, region p11.2-p12.1.
      Northern blot analysis suggested that p53BP3 was broadly expressed in human
      tissues. A further study showed that p53BP3 had a homologue in mouse.
FAU - Zhou, R
AU  - Zhou R
AD  - State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry,
      Chinese Academy of Science, Shanghai 200031, People's Republic of China.
FAU - Wen, H
AU  - Wen H
FAU - Ao, S Z
AU  - Ao SZ
LA  - eng
SI  - GENBANK/U82939
PT  - Journal Article
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Localization Signals)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.3.2.27 (TOPORS protein, human)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Carrier Proteins/*genetics/*metabolism
MH  - Chromosomes, Human, Pair 12/genetics
MH  - Cloning, Molecular
MH  - *DNA-Binding Proteins
MH  - *Genes
MH  - HeLa Cells
MH  - Humans
MH  - Leucine Zippers
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Neoplasm Proteins
MH  - Nuclear Localization Signals
MH  - Nuclear Proteins/chemistry/genetics/metabolism
MH  - Physical Chromosome Mapping
MH  - Protein Binding
MH  - RNA, Messenger/analysis/genetics
MH  - Recombinant Fusion Proteins/chemistry/metabolism
MH  - Sequence Deletion
MH  - *Transcription Factors
MH  - Transfection
MH  - Tumor Cells, Cultured
MH  - Tumor Suppressor Protein p53/genetics/*metabolism
MH  - Ubiquitin-Protein Ligases
MH  - Yeasts/genetics
EDAT- 1999/07/23 00:00
MHDA- 1999/07/23 00:01
CRDT- 1999/07/23 00:00
PHST- 1999/07/23 00:00 [pubmed]
PHST- 1999/07/23 00:01 [medline]
PHST- 1999/07/23 00:00 [entrez]
AID - S0378-1119(99)00203-6 [pii]
AID - 10.1016/s0378-1119(99)00203-6 [doi]
PST - ppublish
SO  - Gene. 1999 Jul 22;235(1-2):93-101. doi: 10.1016/s0378-1119(99)00203-6.