PMID- 10413599
OWN - NLM
STAT- MEDLINE
DCOM- 19990819
LR  - 20191210
IS  - 0014-4827 (Print)
IS  - 0014-4827 (Linking)
VI  - 250
IP  - 2
DP  - 1999 Aug 1
TI  - The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the
      outer limiting zone in the retina, defining a novel type of adhering junction.
PG  - 452-64
AB  - In the retina, special plaque-bearing adhering junctions are aligned to form a
      planar system (the "outer limiting zone," OLZ) of heterotypic connections between
      the photoreceptor cells and the surrounding glial cells ("Muller cells"),
      together with homotypic junctions. In the plaques of these junctions, which
      contain N-cadherin-and possibly also related cadherins-we have identified, by
      immunolocalization techniques, a recently discovered neural tissue-specific
      protein, neurojungin, a member of the plakoglobin/armadillo protein family. In
      these plaques we have also detected other adherens plaque proteins, such as
      alpha- and beta-catenin, protein p120, and vinculin, as well as proteins known as
      constituents of tight junction plaques, such as symplekin and protein ZO-1, and
      the desmosomal plaque protein plakophilin 2. This unusual combination of proteins
      and the demonstrated absence of plakoglobin define the OLZ junctions as a new and
      distinct category of adhering junction, which probably has special architectural 
      functions.
CI  - Copyright 1999 Academic Press.
FAU - Paffenholz, R
AU  - Paffenholz R
AD  - Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany.
FAU - Kuhn, C
AU  - Kuhn C
FAU - Grund, C
AU  - Grund C
FAU - Stehr, S
AU  - Stehr S
FAU - Franke, W W
AU  - Franke WW
LA  - eng
SI  - GENBANK/U52351
SI  - GENBANK/U90331
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (Antibodies)
RN  - 0 (Armadillo Domain Proteins)
RN  - 0 (CTNNB1 protein, mouse)
RN  - 0 (Catenins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Ctnna1 protein, mouse)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Desmoplakins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Pkp2 protein, mouse)
RN  - 0 (Plakophilins)
RN  - 0 (Proteins)
RN  - 0 (SYMPK protein, human)
RN  - 0 (TJP1 protein, human)
RN  - 0 (Tjp1 protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 0 (Zonula Occludens-1 Protein)
RN  - 0 (alpha Catenin)
RN  - 0 (beta Catenin)
RN  - 0 (delta catenin)
RN  - 0 (gamma Catenin)
RN  - 125361-02-6 (Vinculin)
RN  - EC 2.1.1.- (Nop2 protein, mouse)
RN  - EC 2.1.1.- (Protein Methyltransferases)
SB  - IM
MH  - Animals
MH  - Antibodies
MH  - Armadillo Domain Proteins
MH  - Catenins
MH  - Cattle
MH  - Cell Adhesion
MH  - Cell Adhesion Molecules
MH  - Cytoskeletal Proteins/analysis
MH  - Desmoplakins
MH  - Female
MH  - Intercellular Junctions/*chemistry/classification/ultrastructure
MH  - Membrane Proteins/analysis
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Microscopy, Electron
MH  - Microscopy, Fluorescence
MH  - Nerve Tissue Proteins/*analysis
MH  - Nuclear Proteins/analysis
MH  - Phosphoproteins/analysis
MH  - Plakophilins
MH  - Precipitin Tests
MH  - Protein Methyltransferases
MH  - Proteins/analysis
MH  - Retina/cytology/growth & development/*ultrastructure
MH  - *Trans-Activators
MH  - Vinculin/analysis
MH  - Zonula Occludens-1 Protein
MH  - alpha Catenin
MH  - beta Catenin
MH  - gamma Catenin
EDAT- 1999/07/22 00:00
MHDA- 1999/07/22 00:01
CRDT- 1999/07/22 00:00
PHST- 1999/07/22 00:00 [pubmed]
PHST- 1999/07/22 00:01 [medline]
PHST- 1999/07/22 00:00 [entrez]
AID - 10.1006/excr.1999.4534 [doi]
AID - S0014-4827(99)94534-2 [pii]
PST - ppublish
SO  - Exp Cell Res. 1999 Aug 1;250(2):452-64. doi: 10.1006/excr.1999.4534.