PMID- 10409696
OWN - NLM
STAT- MEDLINE
DCOM- 19990826
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 30
DP  - 1999 Jul 23
TI  - Interaction and specificity of Rel-related proteins in regulating Drosophila
      immunity gene expression.
PG  - 21355-61
AB  - NF-kappaB/Rel family proteins regulate genes that are critical for many cellular 
      processes including apoptosis, inflammation, immune response, and development.
      NF-kappaB/Rel proteins function as homodimers or heterodimers, which recognize
      specific DNA sequences within target promoters. We examined the activity of
      different Drosophila Rel-related proteins in modulating Drosophila immunity genes
      by expressing the Rel proteins in stably transfected cell lines. We also compared
      how different combinations of these transcriptional regulators control the
      activity of various immunity genes. The results show that Rel proteins are
      directly involved in regulating the Drosophila antimicrobial response.
      Furthermore, the drosomycin and defensin expression is best induced by the
      Relish/Dif and the Relish/Dorsal heterodimers, respectively, whereas the attacin 
      activity can be efficiently up-regulated by the Relish homodimer and
      heterodimers. These results illustrate how the formation of Rel protein dimers
      differentially regulate target gene expression.
FAU - Han, Z S
AU  - Han ZS
AD  - Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, 
      University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
FAU - Ip, Y T
AU  - Ip YT
LA  - eng
GR  - GM53269/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (NF-kappa B)
RN  - 0 (Oncogene Proteins v-rel)
RN  - 0 (Retroviridae Proteins, Oncogenic)
SB  - IM
MH  - Animals
MH  - Drosophila/*genetics/*immunology
MH  - Gene Expression Regulation/*immunology
MH  - Genes, Insect/immunology
MH  - Immunity/*genetics
MH  - NF-kappa B/*genetics/immunology
MH  - Oncogene Proteins v-rel
MH  - Retroviridae Proteins, Oncogenic/*genetics/immunology
EDAT- 1999/07/20 00:00
MHDA- 1999/07/20 00:01
CRDT- 1999/07/20 00:00
PHST- 1999/07/20 00:00 [pubmed]
PHST- 1999/07/20 00:01 [medline]
PHST- 1999/07/20 00:00 [entrez]
AID - 10.1074/jbc.274.30.21355 [doi]
AID - S0021-9258(19)72585-X [pii]
PST - ppublish
SO  - J Biol Chem. 1999 Jul 23;274(30):21355-61. doi: 10.1074/jbc.274.30.21355.