PMID- 10409430
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20190816
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 59
IP  - 2
DP  - 1999 Jul 15
TI  - MLL2: A new mammalian member of the trx/MLL family of genes.
PG  - 187-92
AB  - We have identified a gene at chromosome band 19q13.1, which is closely related to
      MLL. MLL is located in a region of chromosome 11q23 that has partial synteny with
      chromosome 19q. We have named this gene at 19q13.1, MLL2. MLL2 encodes a protein 
      that exhibits a high level of similarity to MLL over several important protein
      domains. MLL2 is also ubiquitously expressed among adult human tissues, as is
      MLL. MLL is a homologue of the Drosophila gene trithorax (trx), which encodes a
      regulator of homeotic gene expression. MLL is involved in chromosome
      rearrangements associated with leukemia in mammals. However, no MLL2
      rearrangements associated with leukemia have been recorded.
CI  - Copyright 1999 Academic Press.
FAU - FitzGerald, K T
AU  - FitzGerald KT
AD  - Cardinal Bernardin Cancer Center, Loyola University Medical Center, 2160 South
      First Avenue, Maywood, Illinois 60153, USA.
FAU - Diaz, M O
AU  - Diaz MO
LA  - eng
SI  - GENBANK/AF104918
SI  - GENBANK/AF105279
SI  - GENBANK/AF105280
GR  - CA38725/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KMT2A protein, human)
RN  - 0 (KMT2D protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Blotting, Northern
MH  - DNA, Complementary/chemistry/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - Gene Expression
MH  - Genes/*genetics
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - *Neoplasm Proteins
MH  - *Proto-Oncogenes
MH  - RNA, Messenger/genetics/metabolism
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - *Transcription Factors
EDAT- 1999/07/20 00:00
MHDA- 1999/07/20 00:01
CRDT- 1999/07/20 00:00
PHST- 1999/07/20 00:00 [pubmed]
PHST- 1999/07/20 00:01 [medline]
PHST- 1999/07/20 00:00 [entrez]
AID - 10.1006/geno.1999.5860 [doi]
AID - S0888-7543(99)95860-3 [pii]
PST - ppublish
SO  - Genomics. 1999 Jul 15;59(2):187-92. doi: 10.1006/geno.1999.5860.