PMID- 10409308
OWN - NLM
STAT- MEDLINE
DCOM- 19990830
LR  - 20181106
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 277
IP  - 1
DP  - 1999 Jul
TI  - Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney.
PG  - F146-56
LID - 10.1152/ajprenal.1999.277.1.F146 [doi]
AB  - The potential for Ksp-cadherin involvement in either the development or
      maintenance of the metanephric kidney was assessed by immunocytochemical
      localization of a monoclonal antibody directed against the rabbit isoform of
      Ksp-cadherin in both neonatal and adult rabbit kidneys. In the adult kidney
      Ksp-cadherin expression was detected on the basolateral membrane of all cell
      types in both the tubular nephron and the collecting system. Immunoelectron
      microscopy indicated that Ksp-cadherin was expressed at uniform levels along the 
      entire length of both the lateral membranes and the basal infoldings of all
      tubular epithelial cell types. In the nephrogenic zone of the neonatal rabbit
      kidney Ksp-cadherin expression was detected exclusively on the basolateral
      membranes of epithelial cells in the more highly differentiated regions of the
      expanding ureteric duct. In the highly differentiated corticomedullary and
      medullary regions of the neonatal kidney, distinct basolateral staining was
      observed in all segments of the tubular nephron and the collecting system. The
      relatively late appearance of Ksp-cadherin expression in the developing
      metanephros indicates that Ksp-cadherin probably does not participate in the
      direction of renal morphogenesis. However, the high levels of Ksp-cadherin
      expression observed in all segments of the tubular nephron and the collecting
      system in the adult kidney suggests that it may play a role in the maintenance of
      the terminally differentiated tubular epithelial phenotype.
FAU - Thomson, R B
AU  - Thomson RB
AD  - Section of Nephrology, Departments of Internal Medicine and of Cellular and
      Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 
      06520-8029, USA. thomson@biomed.med.yale.edu
FAU - Aronson, P S
AU  - Aronson PS
LA  - eng
GR  - DK-17433/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Cadherins)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Cadherins/*analysis/biosynthesis/*immunology
MH  - Fluorescent Antibody Technique
MH  - Kidney/chemistry/*growth & development/*immunology
MH  - Rabbits
EDAT- 1999/07/17 00:00
MHDA- 1999/07/17 00:01
CRDT- 1999/07/17 00:00
PHST- 1999/07/17 00:00 [pubmed]
PHST- 1999/07/17 00:01 [medline]
PHST- 1999/07/17 00:00 [entrez]
AID - 10.1152/ajprenal.1999.277.1.F146 [doi]
PST - ppublish
SO  - Am J Physiol. 1999 Jul;277(1):F146-56. doi: 10.1152/ajprenal.1999.277.1.F146.