PMID- 10407229
OWN - NLM
STAT- MEDLINE
DCOM- 19990819
LR  - 20190905
IS  - 0804-4643 (Print)
IS  - 0804-4643 (Linking)
VI  - 141
IP  - 1
DP  - 1999 Jul
TI  - Missense variants in the human peroxisome proliferator-activated receptor-gamma2 
      gene in lean and obese subjects.
PG  - 90-2
AB  - The peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) is almost
      uniquely expressed in adipose tissue and is of major importance for fat cell
      differentiation and lipid metabolism. This study was undertaken to assess whether
      two missense variants in the PPARgamma2 gene are associated with early-onset
      obesity. A previously described polymorphism encoding for an amino acid exchange 
      in codon 12 (Pro12Ala) was detected with allele frequencies of 0.13 in 296
      markedly obese children and adolescents and 0.14 in 130 lean individuals. A
      Pro115Gln variant, which had been linked to obesity in Germans in a previous
      association study, was not detected in any of our obese or lean subjects, who are
      also of German origin. We conclude from our data that these two variants in the
      PPARgamma2 gene are unlikely to contribute to the high prevalence of early-onset 
      obesity.
FAU - Hamann, A
AU  - Hamann A
AD  - Medizinische Kernklinik und Poliklinik, Universitats-Krankenhaus Eppendorf,
      Hamburg, Germany.
FAU - Munzberg, H
AU  - Munzberg H
FAU - Buttron, P
AU  - Buttron P
FAU - Busing, B
AU  - Busing B
FAU - Hinney, A
AU  - Hinney A
FAU - Mayer, H
AU  - Mayer H
FAU - Siegfried, W
AU  - Siegfried W
FAU - Hebebrand, J
AU  - Hebebrand J
FAU - Greten, H
AU  - Greten H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Transcription Factors)
RN  - EC 3.1.21.- (endodeoxyribonuclease HgaI)
RN  - EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Deoxyribonucleases, Type II Site-Specific
MH  - Humans
MH  - *Mutation, Missense
MH  - Obesity/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - Receptors, Cytoplasmic and Nuclear/*genetics
MH  - Transcription Factors/*genetics
EDAT- 1999/07/17 00:00
MHDA- 1999/07/17 00:01
CRDT- 1999/07/17 00:00
PHST- 1999/07/17 00:00 [pubmed]
PHST- 1999/07/17 00:01 [medline]
PHST- 1999/07/17 00:00 [entrez]
AID - 1410090 [pii]
AID - 10.1530/eje.0.1410090 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 1999 Jul;141(1):90-2. doi: 10.1530/eje.0.1410090.