PMID- 10407168
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20200124
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 70
IP  - 2
DP  - 1999 Jul 5
TI  - Molecular characterization of a new member of the protein 4.1 family (brain 4.1) 
      in rat brain.
PG  - 197-209
AB  - In addition to the well-known erythroid 4.1 gene, two human genes (KIAA0338 and
      4.1G) have recently been identified as members of the protein 4.1 family of
      genes. We compared the expression levels of these three genes and found that the 
      KIAA0338 gene was predominantly expressed in human brain. To further characterize
      this novel protein 4.1, called brain 4.1, we isolated rat brain 4.1 cDNA and
      analyzed its gene products in rat brain. The results indicated that the mRNA and 
      protein products of the brain 4.1 gene were more abundant in brain compared to
      any other tissues examined. The brain 4.1 mRNA appeared as multiple bands with
      estimated sizes of 3.9 kb, 6.2 kb and 8.7 kb on RNA blotting analysis, and was
      found to consist of various alternative forms as reported previously for the
      erythroid 4. 1 gene. As for the brain 4.1 gene product, many isoforms discernible
      by immunoblotting analysis were also observed depending on the tissue type and
      the brain region. The existence of multiple forms of the brain 4.1 implies that
      it has multiple and diverse functions like the erythroid 4.1 gene product.
CI  - Copyright 1999 Elsevier Science B.V.
FAU - Yamakawa, H
AU  - Yamakawa H
AD  - Laboratory of DNA Technology, Kazusa DNA Research Institute, 1532-3 Yana,
      Kisarazu, Chiba 292-0812, Japan.
FAU - Ohara, R
AU  - Ohara R
FAU - Nakajima, D
AU  - Nakajima D
FAU - Nakayama, M
AU  - Nakayama M
FAU - Ohara, O
AU  - Ohara O
LA  - eng
SI  - GENBANK/AB019256
SI  - GENBANK/AB019257
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA Primers)
RN  - 0 (Epb41l1 protein, rat)
RN  - 0 (Membrane Proteins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - 0 (erythrocyte membrane band 4.1 protein)
RN  - 0 (erythrocyte membrane protein band 4.1-like 1)
SB  - IM
EIN - Brain Res Mol Brain Res 1999 Dec 10;74(1-2):247
MH  - 3' Untranslated Regions/chemistry/genetics
MH  - Adult
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/*metabolism
MH  - *Cytoskeletal Proteins
MH  - DNA Primers
MH  - Erythrocyte Membrane/metabolism
MH  - Gene Library
MH  - Humans
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Microfilament Proteins
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/chemistry/*genetics
MH  - *Neuropeptides
MH  - Organ Specificity
MH  - Polymerase Chain Reaction
MH  - Protein Isoforms/chemistry/genetics
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Transcription, Genetic
EDAT- 1999/07/17 10:00
MHDA- 2000/03/11 09:00
CRDT- 1999/07/17 10:00
PHST- 1999/07/17 10:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 1999/07/17 10:00 [entrez]
AID - S0169328X99001394 [pii]
AID - 10.1016/s0169-328x(99)00139-4 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1999 Jul 5;70(2):197-209. doi:
      10.1016/s0169-328x(99)00139-4.