PMID- 10407135
OWN - NLM
STAT- MEDLINE
DCOM- 19990913
LR  - 20061115
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 115
IP  - 2
DP  - 1999 Jun 2
TI  - A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing
      brain.
PG  - 183-93
AB  - We have identified and characterized a new member of the mammalian brain-specific
      T-box gene family, Tbr2, which is closely related to mouse Tbr1, and to the
      Xenopus earliest mesodermal gene, Eomesodermin. As Tbr1, Tbr2 is predominantly
      expressed in some regions of the developing brain, but in a strikingly
      complementary manner. On embryonic day 14.5 (E14.5), Tbr2 mRNA expression was
      observed in the mesencephalon and rhombencephalon in contrast to Tbr1 which was
      expressed mostly in the telencephalon. At this stage, Tbr2 mRNA was readily
      detectable in the postmitotic and differentiating neurons located in various
      brain regions, i.e., oculomotor, red, trigeminal, vestibular, facial, and
      hypoglossal nuclei. However, expression of Tbr2 in these nuclei became
      undetectable on E18.5. In contrast, Tbr2 mRNA expression was detected in the
      hippocampus only from E18.5 onwards. Whereas Tbr2 expression disappeared in most 
      parts of the mature adult brain, it remained detectable in the hippocampus and
      olfactory bulb, regions where some neuronal precursors retain their
      differentiation potential. These results suggest that Tbr2 may play a crucial
      role in differentiating neurons rather than in proliferating or already
      differentiated neurons. In addition, similarly to Xenopus Eomesodermin, mouse
      Tbr2 showed biphasic expression; a first peak around E6.5 and a second peak
      around E14.5, suggesting that Tbr2 may also be important at early stages of
      gastrulation.
CI  - Copyright 1999 Elsevier Science B.V.
FAU - Kimura, N
AU  - Kimura N
AD  - Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical
      and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
FAU - Nakashima, K
AU  - Nakashima K
FAU - Ueno, M
AU  - Ueno M
FAU - Kiyama, H
AU  - Kiyama H
FAU - Taga, T
AU  - Taga T
LA  - eng
SI  - GENBANK/AB031037
SI  - GENBANK/AB031038
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (EOMES protein, human)
RN  - 0 (Eomes protein, mouse)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (T-Box Domain Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/embryology/*metabolism
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/*genetics
MH  - Embryonic and Fetal Development/physiology
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - *Genes, Homeobox
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - *Nerve Tissue Proteins
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - *T-Box Domain Proteins
EDAT- 1999/07/17 00:00
MHDA- 1999/07/17 00:01
CRDT- 1999/07/17 00:00
PHST- 1999/07/17 00:00 [pubmed]
PHST- 1999/07/17 00:01 [medline]
PHST- 1999/07/17 00:00 [entrez]
AID - S0165380699000644 [pii]
PST - ppublish
SO  - Brain Res Dev Brain Res. 1999 Jun 2;115(2):183-93.